NDLI: Simvastatin Therapy Reduces Prooxidant-Antioxidant Balance: Results of a Placebo-Controlled Cross-Over Trial

Content Provider	Springer Nature Link
Author	Parizadeh, Seyyed M. R. Azarpazhooh, Mahmoud R. Moohebati, Mohsen Nematy, Mohsen Ghayour Mobarhan, Majid Tavallaie, Shima Rahsepar, Amir A. Amini, Maral Sahebkar, Amirhossein Mohammadi, Maryam Ferns, Gordon A. A.
Copyright Year	2011
Abstract	Oxidative stress is thought to play an important role in atherogenesis. The statin group of cholesterol-lowering drugs have been shown to reduce cardiovascular events and possess antioxidant properties. We aimed to assess the effects of simvastatin on a novel measure of prooxidant–antioxidant balance (PAB) in dyslipidemic patients. The PAB assay can measure the prooxidant burden and the antioxidant capacity simultaneously in one assay, thereby giving a redox index. We treated 102 dyslipidemic individuals with simvastatin, or a placebo in a double-blind, cross-over, placebo-controlled trial. PAB values were measured before and after each treatment period. Seventy-seven subjects completed the study. We found that statin therapy was associated with a significant reduction in PAB values (P < 0.001). This effect appeared to be independent of the cholesterol-lowering effects of statins. We conclude that serum PAB values are decreased by simvastatin therapy. Regarding previous reports on the elevation of PAB in conditions associated with oxidative stress, the PAB assay, along with other markers of oxidative stress, may be applied to estimate the extent of oxidative stress in patients, assessment of the antioxidative efficacy of medication such as statins and perhaps also for the identification of those individuals who need antioxidant therapy.
Starting Page	333
Ending Page	340
Page Count	8
File Format	PDF
ISSN	00244201
Journal	Lipids
Volume Number	46
Issue Number	4
e-ISSN	15589307
Language	English
Publisher	Springer-Verlag
Publisher Date	2011-01-05
Publisher Place	Berlin, Heidelberg
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Simvastatin Prooxidant–antioxidant balance (PAB) Dyslipidemia Nutrition Medicinal Chemistry Medical Biochemistry Neurochemistry Lipidology Microbial Genetics and Genomics
Content Type	Text
Resource Type	Article
Subject	Cell Biology Organic Chemistry Biochemistry

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