NDLI: Serum Lipoprotein(a) Levels are Greater in Female than Male Patients with Type-2 Diabetes

Content Provider	Springer Nature Link
Author	Nakhjavani, Mauchehr Morteza, Afsaneh Esteghamati, Alireza Khalilzadeh, Omid Zandieh, Ali Safari, Reza
Copyright Year	2010
Abstract	Women with diabetes are faced with a higher risk of dyslipidemia and cardiovascular disorders than men with diabetes. We aimed to study the role of gender and menopausal status in serum Lp(a) levels in patients with type 2 diabetes. We quantified serum Lp(a) levels in a group of 477 patients with type 2 diabetes (men, premenopausal and postmenopausal women with diabetes), as well as in 105 controls. We stratified the patients into two groups of low Lp(a) levels (Lp(a) <35 mg/dl) and elevated Lp(a) levels (Lp(a) >35 mg/dl). Patients with diabetes had higher serum Lp(a) levels than the controls. Serum Lp(a) levels was significantly higher in women with diabetes than men with diabetes. Lp(a) levels did not differ between male and females in the control group. Premenopausal and postmenopausal women with diabetes did not differ significantly in serum Lp(a) levels. The odds ratio of having a serum Lp(a) level higher than 35 was 5.85 in premenopausal women with diabetes, 5.08 in postmenopausal women with diabetes, 2.41 in men with diabetes and 1.9 in the women in the control group compared to the men in the control group, after adjustment for age and BMI. This observational study clearly indicated that serum Lp(a) levels were significantly higher in women and men with diabetes. The increase in women was independent of menopause. The level of serum Lp(a) had no correlation with lipid parameters in men or women.
Starting Page	349
Ending Page	356
Page Count	8
File Format	PDF
ISSN	00244201
Journal	Lipids
Volume Number	46
Issue Number	4
e-ISSN	15589307
Language	English
Publisher	Springer-Verlag
Publisher Date	2010-12-14
Publisher Place	Berlin, Heidelberg
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Lipoprotein(a) Type 2 diabetes Dyslipidemia Women Menopause Nutrition Medicinal Chemistry Medical Biochemistry Neurochemistry Lipidology Microbial Genetics and Genomics
Content Type	Text
Resource Type	Article
Subject	Cell Biology Organic Chemistry Biochemistry

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