NDLI: Characterization of biochemical markers of blood-brain-barrier permeability and the functioning of the central nervous system

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Characterization of biochemical markers of blood-brain-barrier permeability and the functioning of the central nervous system

Content Provider	Springer Nature Link
Author	Bliv, D. V. Terent’ev, A. A.
Copyright Year	2013
Abstract	The content of different biomarkers in the blood and cerebrospinal fluid is one of the most informative biochemical indicators of the state of the blood-brain barrier (BBB). The neuron-specific proteins (NSPs) outside the brain may be considered as markers of a pathological process. To date, more than 120 NSPs have more or less detailed descriptions. To evaluate the state of the BBB, it is rational to use the most studied proteins, viz., the markers of neurons and astrocytes. These are the glial fibrillary acidic protein (GFAP), neuron-specific enolase (NSE), and proteins of the S100 family. They do not cross the BBB and practically cannot be detected in serum under normal conditions. When BBB permeability is compromised, NSPs penetrate into the peripheral blood and may be measured there. Vascular endothelial growth factor (VEGF) may be important for diagnostics for the evaluation of the state of a major component of the BBB, viz., the endothelial cells. Dynamic assessment of the serum levels of NSPs and the VEGF may be used to evaluate BBB resistance and the severity of CNS lesions.
Starting Page	159
Ending Page	170
Page Count	12
File Format	PDF
ISSN	18197124
Journal	Neurochemical Journal
Volume Number	7
Issue Number	3
e-ISSN	18197132
Language	English
Publisher	Springer US
Publisher Date	2013-08-28
Publisher Place	Boston
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	CNS NSP NSE GFAP S100 VEGF BBB Neurosciences
Content Type	Text
Resource Type	Article
Subject	Molecular Biology Biochemistry Cellular and Molecular Neuroscience

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