NDLI: The role of opioid receptor agonists and antagonists in the treatment of Parkinson’s disease

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Neurochemical Journal : Volume 1, Issue 3, September 2007

Neurochemical Journal : Volume 1, Issue 2, June 2007

Neurochemical Journal : Volume 1, Issue 1, March 2007

The role of opioid receptor agonists and antagonists in the treatment of Parkinson’s disease

Content Provider	Springer Nature Link
Author	Silkis, I. G.
Copyright Year	2007
Abstract	A possible mechanism underlying the role of opioids in the treatment of Parkinson’s disease and L-dopa-induced dyskinesias is suggested. This role is based on the reorganization of neuronal firing in the motor cortico-basal ganglia-thalamocortical loop as a consequence of opioid-mediated LTD induction in the spiny cells of the input basal ganglia nucleus, striatum. Analysis of existing data allowed us to propose that the striatonigral cells in the striosomes and matrix that release dynorphin mainly express μ and κ opioid receptors, respectively, whereas striatopallidal cells that release enkephalin express δ opioid receptors. The proposed mechanism implies that in addition to agonists of dopamine receptors and antagonists of muscarinic receptors, μ and δ receptor agonists and/or κ receptor antagonists might alleviate the symptoms of Parkinson’s disease and allow recovery of locomotor activity. Recurrent collaterals of striatal spiny cells innervating their dendrites and bodies, as well as those of striatal cholinergic interneurons, form negative feedback loops that allow opioid peptides and substance P to regulate and stabilize striatal output pathways. Therefore, in the absence of activation of the D2 and D1 receptors on striatal spiny cells, increased enkephalin concentration and decreased dynorphin and substance P level promote the suppression of acetylcholine release (due to modulation of cholinergic interneuron firing through κ opioid and NK receptors), thus reducing the impact of a dopamine deficit on basal ganglia functioning. Opposing changes in opioid concentrations, due to L-dopa treatment and reorganization of activity in the same neuronal loops, may reduce dyskinesias.
Starting Page	281
Ending Page	287
Page Count	7
File Format	PDF
ISSN	18197124
Journal	Neurochemical Journal
Volume Number	1
Issue Number	4
e-ISSN	18197132
Language	English
Publisher	Allerton Press, Inc.
Publisher Date	2007-01-01
Publisher Place	New York
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	opioids Parkinson’s disease basal ganglia synaptic plasticity dyskinesia Neurosciences
Content Type	Text
Resource Type	Article
Subject	Molecular Biology Biochemistry Cellular and Molecular Neuroscience

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