NDLI: Effect of particle size of calcium phosphate based bioceramic drug delivery carrier on the release kinetics of ciprofloxacin hydrochloride: an in vitro study

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Effect of particle size of calcium phosphate based bioceramic drug delivery carrier on the release kinetics of ciprofloxacin hydrochloride: an in vitro study

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Frontiers of Materials Science in China : Volume 7, Issue 2, June 2013

Frontiers of Materials Science in China : Volume 7, Issue 1, March 2013

Frontiers of Materials Science in China : Volume 6

Frontiers of Materials Science in China : Volume 5

Frontiers of Materials Science in China : Volume 4

Frontiers of Materials Science in China : Volume 3

Frontiers of Materials Science in China : Volume 2

Frontiers of Materials Science in China : Volume 1

Effect of particle size of calcium phosphate based bioceramic drug delivery carrier on the release kinetics of ciprofloxacin hydrochloride: an in vitro study

Content Provider	Springer Nature Link
Author	Sasikumar, Swamiappan
Copyright Year	2013
Abstract	Hydroxyapatite (HAP) is the constituent of calcium phosphate based bone cement and it is extensively used as a bone substitute and drug delivery vehicle in various biomedical applications. In the present study we investigated the release kinetics of ciprofloxacin loaded HAP and analyzed its ability to function as a targeted and sustained release drug carrier. Synthesis of HAP was carried out by combustion method using tartaric acid as a fuel and nitric acid as an oxidizer. Powder XRD and FTIR techniques were employed to characterize the phase purity of the drug carrier and to verify the chemical interaction between the drug and carrier. The synthesized powders were sieve separated to make two different drug carriers with different particle sizes and the surface topography of the pellets of the drug carrier was imaged by AFM. Surface area and porosity of the drug carrier was carried out using surface area analyzer. The in-vitro drug release kinetics was performed in simulated body fluid, at 37.3°C. The amount of ciprofloxacin released is measured using UV-visible spectroscopy following the characteristic λ $_{max}$ of 278 nm. The release saturates around 450 h which indicates that it can be used as a targeted and sustained release carrier for bone infections.
Starting Page	261
Ending Page	268
Page Count	8
File Format	PDF
ISSN	2095025X
Journal	Frontiers of Materials Science in China
Volume Number	7
Issue Number	3
e-ISSN	20950268
Language	English
Publisher	Springer Berlin Heidelberg
Publisher Date	2013-08-16
Publisher Institution	Chinese Universities
Publisher Place	Berlin, Heidelberg
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	ceramic drug delivery system antibiotic hydroxyapatite (HAP) porosity targeted release Materials Science
Content Type	Text
Resource Type	Article
Subject	Materials Science

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Effect of particle size of calcium phosphate based bioceramic drug delivery carrier on the release kinetics of ciprofloxacin hydrochloride: an in vitro study

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Effect of particle size of calcium phosphate based bioceramic drug delivery carrier on the release kinetics of ciprofloxacin hydrochloride: an in vitro study