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  1. Journal of Wuhan University of Technology-Mater. Sci. Ed.
  2. Journal of Wuhan University of Technology-Mater. Sci. Ed. : Volume 22
  3. Journal of Wuhan University of Technology-Mater. Sci. Ed. : Volume 22, Issue 1, February 2007
  4. Preparation of hollow porous HAP microspheres as drug delivery vehicles
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Journal of Wuhan University of Technology-Mater. Sci. Ed. : Volume 32
Journal of Wuhan University of Technology-Mater. Sci. Ed. : Volume 31
Journal of Wuhan University of Technology-Mater. Sci. Ed. : Volume 30
Journal of Wuhan University of Technology-Mater. Sci. Ed. : Volume 29
Journal of Wuhan University of Technology-Mater. Sci. Ed. : Volume 28
Journal of Wuhan University of Technology-Mater. Sci. Ed. : Volume 27
Journal of Wuhan University of Technology-Mater. Sci. Ed. : Volume 26
Journal of Wuhan University of Technology-Mater. Sci. Ed. : Volume 25
Journal of Wuhan University of Technology-Mater. Sci. Ed. : Volume 24
Journal of Wuhan University of Technology-Mater. Sci. Ed. : Volume 23
Journal of Wuhan University of Technology-Mater. Sci. Ed. : Volume 22
Journal of Wuhan University of Technology-Mater. Sci. Ed. : Volume 22, Issue 4, December 2007
Journal of Wuhan University of Technology-Mater. Sci. Ed. : Volume 22, Issue 3, September 2007
Journal of Wuhan University of Technology-Mater. Sci. Ed. : Volume 22, Issue 2, June 2007
Journal of Wuhan University of Technology-Mater. Sci. Ed. : Volume 22, Issue 1, February 2007
Effects of phosphorus grain boundary segregation and hardness on the ductile-to-brittle transition for a 2.25Cr1Mo steel
Preparation and microstructural analysis of Ti$_{2}$AlC/TiAl(Nb) composite
Effects of Mo composites on the corrosion behaviors of low alloy steel
Deformation and densification laws of powder cold forging
Kinetic equation for internal oxidation of Cu-Al alloy spheres
Electronic structures and bonding properties of Ti$_{2}$AlC and Ti$_{3}$AlC$_{2}$
Preparation of porous ceramisite for waste water treatment made from red mud
Long-term performance of moderate heat Portland cement with double-expansive sources
The effect of surface etching and dation on the permeability spectrum of nanocrystalline Fe$_{85-x }$Co$_{ x }$Nb$_{7}$B$_{8}$ ribbon
Observation and analysis of gypsum particleboard using SEM
Self-propagating high-temperature reductive synthesis of TiB$_{2}$-Al$_{2}$O$_{3}$ composite powders
Effect of polypropylene fibers on the long-term tensile strength of concrete
Composition design for high C$_{3}$S cement clinker and its mineral formation
Microstructure formation and degradation mechanism of cementitious plugging agent slurries
The transmission modes and losses of the poled nano-crystal and polymer composite PbTiO$_{3}$/PEK-c thin-film waveguides
The design and properties of G.656 optical fiber waveguide design
Sr microalloying for refining grain size of AZ91D Magnesium alloy
Preparation and properties of IrO$_{2}$ thin films grown by pulsed laser deposition technique
Experimental investigation on flexural performance of masonry walls reinforced with GFRP
The synthesis and electrorheological properties of BaTiO$_{3}$-coated PMMA microspheres
Effects of annealing temperature on the electrical conductivity and mechanical property of Cu-Te alloys
Relationship between liquid phase content and the orientation of PMNT ceramics by TGG method
Synthesis of fullerene by pyrolysis of acetylene in thermal HF-Plasma
Effect of β-TCP ceramic on the total protein of osteoblasts
Fabrication and properties of multilayer chitosan membrane loaded with tinidazole
Influences of carboxyl methyl cellulose on performances of mortar
PEGylated PLGA nanoparticles as tumor ecrosis factor-α receptor blocking peptide carriers: Preparation, characterization and release in vitro
Soluble eggshell mebrane protein: Antibacterial property and biodegradability
Hydrothermal synthesis and characterization of a novel organic inorganic hybrid compound [Co(dien)$_{2}$] (dienH$_{3}$)(H$_{3}$O)$_{7}$[P$_{2}$Mo$_{5}$O$_{23}$]$_{2}$·14H$_{2}$O
Preparation and microstrutures of BSTO/MgO ferroelectric materials for phase shift
Preparation and properties of a-Si:H thin films deposited on different substrates
Effect of thermal treatment and acid leaching process on pore characteristics of nanometer porous glass
Reducing the compaction segregation of hot mix asphalt
Low temperature coating of anatase thin films on silica glass fibers by liquid phase deposition
Electrodeposition and characterization of CuInSe$_{2}$ thin films for solar cells
Preparation of bauxite ceramic microsphere
Microwave irradiation treatment of wood flour and its application in PVC-wood flour composites
Thermal behavior and rheological properties of PANI-DBSA/PAN blends
The Complex of crosslinked chitosan with 4′-formal benzo-15-crown-5 and palladium used as catalyst for asymmetric hydrogenation of α-phenylethanone
Formation and characterization of Pd, Pt and Pd-Pt alloy films on polyimide by catalyst-enhanced chemical vapor deposition
Influence of particle size on piezoelectricity of piezo-composites
Effects of heat treatment temperature and time on structure and static magnetic property of W-type ferrite hollow microspheres
Investigation of the thermal decomposition properties of polyoxymethylene
Preparation of hollow porous HAP microspheres as drug delivery vehicles
Journal of Wuhan University of Technology-Mater. Sci. Ed. : Volume 21
Journal of Wuhan University of Technology-Mater. Sci. Ed. : Volume 20
Journal of Wuhan University of Technology-Mater. Sci. Ed. : Volume 19
Journal of Wuhan University of Technology-Mater. Sci. Ed. : Volume 18
Journal of Wuhan University of Technology-Mater. Sci. Ed. : Volume 17

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Preparation of hollow porous HAP microspheres as drug delivery vehicles

Content Provider Springer Nature Link
Author Wang, Qing Huang, Wenhai Wang, Deping
Copyright Year 2007
Abstract Hollow HAP microspheres in sub-millimeter size were prepared and investigated as a drug delivery vehicle. The LCB (lithium-calcium borate) glass microspheres, which were made through flame spray process, were chosen as precursor for hollow HAP microspheres. The LCB glass microspheres reacted with phosphate buffer (K$_{2}$HPO$_{4}$) solution for 5 days at 37 °C. During the reaction the Ca-P-OH compound precipitated on the surface of LCB glass microspheres and formed porous shells. Then the microspheres turned to be hollow ones with the same diameter as the glass microspheres after LCB glass run out in the chemical reaction. After heat-treated at 600 ° for 4 h, the Ca-P-OH compound became HAP, thus the hollow HAP microspheres were produced. The mechanism of forming hollow HAP microspheres through the chemical reaction between phosphate buffer and LCB glass was confirmed by the XRD analysis. The microstructure characteristics of the hollow, porous microspheres were observed by SEM.
Starting Page 174
Ending Page 177
Page Count 4
File Format PDF
ISSN 10002413
Journal Journal of Wuhan University of Technology-Mater. Sci. Ed.
Volume Number 22
Issue Number 1
e-ISSN 19930437
Language English
Publisher Wuhan University of Technology
Publisher Date 2007-01-01
Publisher Place Wuhan
Access Restriction One Nation One Subscription (ONOS)
Subject Keyword hollow HAP microsphere drug delivery vehicle hydroxyapatite Materials Science
Content Type Text
Resource Type Article
Subject Materials Science
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