NDLI: Polymer-directed assembly of water-soluble realgar nanocomposites for antimicrobial applications

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Frontiers of Materials Science in China : Volume 4, Issue 3, September 2010

Frontiers of Materials Science in China : Volume 4, Issue 2, June 2010

Frontiers of Materials Science in China : Volume 4, Issue 1, March 2010

Frontiers of Materials Science in China : Volume 3

Frontiers of Materials Science in China : Volume 2

Frontiers of Materials Science in China : Volume 1

Polymer-directed assembly of water-soluble realgar nanocomposites for antimicrobial applications

Content Provider	Springer Nature Link
Author	Ou, Sheng Ju Shen, Xing Can Jin, Tao Xie, Jun Guo, Yan Fang Liang, Hong Hou, Ruo Bing
Copyright Year	2010
Abstract	The poor water-solubility of realgar unfortunately results in poor bioavailability and hampers its medicinal application. In this work, water-soluble realgar nanoparticles (As$_{4}$S$_{4}$ NPs) were synthesized in aqueous solution and characterized by X-ray photoelectron spectroscopy. Furthermore, a polymer directed assembly method was used to prepare for the As$_{4}$S$_{4}$ nanocomposites with beneficial bioavailability for antimicrobial applications. It is found that the polyvinylpyrrolidone (PVP) has a significant effect on formation and growth of quasispherical As$_{4}$S$_{4}$-PVP nanocomposite with a narrow size distribution of (65±5) nm. In the case of using carboxymethylcellulose (CMC), the dendritic As$_{4}$S$_{4}$-CMC nanocomposite was obtained with particle size of (120±25) nm in predominant length. The FTIR spectra studies demonstrated the interaction between the polymers and the assembled As$_{4}$S$_{4}$. The antimicrobial assays indicated that the stabilized As$_{4}$S$_{4}$-polymer nanocomposites showed superior antimicrobial activity against uncoated As$_{4}$S$_{4}$ NPs both on gram-positive bacteria Staphylococcus aureus and gram-negative bacteria Escherichia coli. The TEM images of bacterial ultrathin sections showed the damage and disorganization of cell wall, suggesting the membrane-associated antimicrobial activity of As$_{4}$S$_{4}$-PVP nanocomposite.
Starting Page	339
Ending Page	344
Page Count	6
File Format	PDF
ISSN	16737377
Journal	Frontiers of Materials Science in China
Volume Number	4
Issue Number	4
e-ISSN	16737482
Language	English
Publisher	SP Higher Education Press
Publisher Date	2010-11-12
Publisher Institution	Chinese Universities
Publisher Place	Heidelberg
Access Restriction	Subscribed
Subject Keyword	realgar nanocomposite antimicrobial activity polymer water-soluble Materials Science
Content Type	Text
Resource Type	Article
Subject	Materials Science

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