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The pathway of HAP nanoparticle uptake into hepatoma carcinoma cells

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Frontiers of Materials Science in China : Volume 4, Issue 3, September 2010

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Frontiers of Materials Science in China : Volume 3

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The pathway of HAP nanoparticle uptake into hepatoma carcinoma cells

Content Provider	Springer Nature Link
Author	Yin, Mei Zhen Cao, Xian Ying Li, Shi Pu
Copyright Year	2010
Abstract	To study the pathway of hydroxyapatite (HAP) nanoparticle uptake into hepatoma carcinoma cells, by selecting bigger particles as contrast, HAP particles with 70.8, 1078.8, and 1906.6 nm mean diameters were prepared. Using TEM, the distribution conditions of the three kinds of HAP particles on the cell membrane surface and within the endochylema, as well as the change in lysosomes was observed after HAP particles were treated onto Bel-7402 cells for 2, 12, 24, and 48 h. The results showed that there were HAP nanoparticles adhering to the depressed part of the plasmalemma, and in the endochylema there were HAP nanoparticles which were enclosed in many vesicles with different sizes. The lysosome had no changes compared to the blank control. The same results were seen for bigger particle groups. Through contrast analysis, it was thought that HAP nanoparticles were internalized into the hepatoma carcinoma cells and then formed vesicles. HAP nanoparticles enclosed in vesicles did not undergo lysosomal digestion. These characteristics are in accord with non-clathrin-mediated endocytosis. Therefore, the pathway of HAP nanoparticle uptake into hepatoma carcinoma cells is possibly caveolae-mediated endocytosis and it has no relation to particle size. This result lays the foundation for further research into the anticancer mechanism of HAP nanoparticles, and plays an important role in the research on nanoparticles as carriers of anticancer drugs.
Starting Page	376
Ending Page	381
Page Count	6
File Format	PDF
ISSN	16737377
Journal	Frontiers of Materials Science in China
Volume Number	4
Issue Number	4
e-ISSN	16737482
Language	English
Publisher	SP Higher Education Press
Publisher Date	2010-11-08
Publisher Institution	Chinese Universities
Publisher Place	Heidelberg
Access Restriction	Subscribed
Subject Keyword	hydroxyapatite (HAP) nanoparticles hepatoma carcinoma cell endocytosis caveolae Materials Science
Content Type	Text
Resource Type	Article
Subject	Materials Science

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