NDLI: A novel cataplasma matrix of traditional Chinese medicine

Content Provider	Springer Nature Link
Author	Tian, Jing Zhang, Xiaolei Zhou, Xueqin
Copyright Year	2010
Abstract	The aim of this paper was to develop a cataplasma matrix that can be applicable to both water-soluble and liposoluble drugs. The gellan gum and konjaku were employed as the scaffold materials of the matrix. With polyacrylic acid sodium and oligosaccharides as tacktifier, the formula of the cataplasma matrix was optimized in the orthogonal method as: gellan gum 0.4 g, xanthan gum 0.03 g, konjac glue 0.1 g, glycerin 4 g, Gluco-Adhesive T (GAT) 6 g, Gluco-Adhesive E (GAE) 6 g, polyacrylic acid sodium 0.22 g, and sorbitol 3 g. The 180° peel strength, the tensile strength and the elongation at break was 3.043 N, 0.275 MPa and 91.05%, respectively. Furthermore, the drug-compatibilities of the matrix were investigated with baicalin, berberine and curcumin, which were used as the models of hydrophilic, poor-water-soluble and hydrophobic ingredients. The drug contents could reach 4.12%, 2.42% and 3.75%, while the in vitro release rate were measured as, 361.79, 55.85 and 104.41 μg·cm$^{−2}$·h$^{−1}$ for baicalin, berberine and curcumin, respectively. These results indicated that the obtained matrix had good drug-compatibility and drug-release properties for different ingredients.
Starting Page	91
Ending Page	95
Page Count	5
File Format	PDF
ISSN	16737369
Journal	Frontiers of Chemical Engineering in China
Volume Number	4
Issue Number	1
e-ISSN	16737474
Language	English
Publisher	SP Higher Education Press
Publisher Date	2010-01-12
Publisher Institution	Chinese Universities
Publisher Place	Heidelberg
Access Restriction	Subscribed
Subject Keyword	cataplasma novel matrix traditional Chinese medicine in vitro drug release Nanotechnology Industrial Chemistry/Chemical Engineering
Content Type	Text
Resource Type	Article
Subject	Chemical Engineering

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