NDLI: Hyper-connectivity of the thalamus during early stages following mild traumatic brain injury

Content Provider	Springer Nature Link
Author	Sours, Chandler George, Elijah O. Zhuo, Jiachen Roys, Steven Gullapalli, Rao P.
Copyright Year	2015
Abstract	The thalamo-cortical resting state functional connectivity of seven sub-thalamic regions were examined in a prospectively recruited population of 77 acute mild TBI (mTBI) patients within the first 10 days (mean 6 ± 3 days) of injury and 35 neurologically intact control subjects using the Oxford thalamic connectivity atlas. Neuropsychological assessments were conducted using the Automated Neuropsychological Assessment Metrics (ANAM). A subset of participants received a magentic resonance spectroscopy (MRS) exam to determine metabolite concentrations in the thalamus and the posterior cingulate cortex. Results show that patients performed worse than the control group on various subtests of ANAM and the weighted throughput score, suggesting reduced cognitive performance at this early stage of injury. Both voxel and region of interest based analysis of the resting state fMRI data demonstrated that acute mTBI patients have increased functional connectivity between the various sub-thalamic regions and cortical regions associated with sensory processing and the default mode network (DMN). In addition, a significant reduction in NAA/Cr was observed in the thalamus in the mTBI patients. Furthermore, an increase in Cho/Cr ratio specific to mTBI patients with self-reported sensory symptoms was observed compared to those without self-reported sensory symptoms. These results provide novel insights into the neural mechanisms of the brain state related to internal rumination and arousal, which have implications for new interventions for mTBI patients with persistent symptoms. Furthermore, an understanding of heightened sensitivity to sensory related inputs during early stages of injury may facilitate enhanced prediction of safe return to work.
Starting Page	550
Ending Page	563
Page Count	14
File Format	PDF
ISSN	19317557
Journal	Brain Imaging and Behavior
Volume Number	9
Issue Number	3
e-ISSN	19317565
Language	English
Publisher	Springer US
Publisher Date	2015-07-08
Publisher Place	New York
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Mild traumatic brain injury Resting state functional connectivity Thalamus $^{1}$H magnetic resonance spectroscopy Neurosciences Neuroradiology Neuropsychology Psychiatry
Content Type	Text
Resource Type	Article
Subject	Neurology Radiology, Nuclear Medicine and Imaging Cognitive Neuroscience Behavioral Neuroscience Neurology (clinical) Cellular and Molecular Neuroscience Psychiatry and Mental Health

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