NDLI: Neuropathology of mild traumatic brain injury: relationship to neuroimaging findings

Content Provider	Springer Nature Link
Author	Bigler, Erin D. Maxwell, William L.
Copyright Year	2012
Abstract	Neuroimaging identified abnormalities associated with traumatic brain injury (TBI) are but gross indicators that reflect underlying trauma-induced neuropathology at the cellular level. This review examines how cellular pathology relates to neuroimaging findings with the objective of more closely relating how neuroimaging findings reveal underlying neuropathology. Throughout this review an attempt will be made to relate what is directly known from post-mortem microscopic and gross anatomical studies of TBI of all severity levels to the types of lesions and abnormalities observed in contemporary neuroimaging of TBI, with an emphasis on mild traumatic brain injury (mTBI). However, it is impossible to discuss the neuropathology of mTBI without discussing what occurs with more severe injury and viewing pathological changes on some continuum from the mildest to the most severe. Historical milestones in understanding the neuropathology of mTBI are reviewed along with implications for future directions in the examination of neuroimaging and neuropathological correlates of TBI.
Starting Page	108
Ending Page	136
Page Count	29
File Format	PDF
ISSN	19317557
Journal	Brain Imaging and Behavior
Volume Number	6
Issue Number	2
e-ISSN	19317565
Language	English
Publisher	Springer-Verlag
Publisher Date	2012-03-21
Publisher Place	New York
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Neuropathology Mild traumatic brain injury Neuroimaging Traumatic axonal injury Diffuse axonal injury Concussion Psychiatry Neurosciences Neuropsychology Neuroradiology
Content Type	Text
Resource Type	Article
Subject	Neurology Radiology, Nuclear Medicine and Imaging Cognitive Neuroscience Behavioral Neuroscience Neurology (clinical) Cellular and Molecular Neuroscience Psychiatry and Mental Health

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