NDLI: Chronic traumatic encephalopathy: neurodegeneration following repetitive concussive and subconcussive brain trauma

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Brain Imaging and Behavior : Volume 6, Issue 1, March 2012

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Brain Imaging and Behavior : Volume 4

Brain Imaging and Behavior : Volume 3

Brain Imaging and Behavior : Volume 2

Brain Imaging and Behavior : Volume 1

Chronic traumatic encephalopathy: neurodegeneration following repetitive concussive and subconcussive brain trauma

Content Provider	Springer Nature Link
Author	Baugh, Christine M. Stamm, Julie M. Riley, David O. Gavett, Brandon E. Shenton, Martha E. Lin, Alexander winski, Christopher J. Cantu, Robert C. McKee, Ann C. Stern, Robert A.
Copyright Year	2012
Abstract	Chronic Traumatic Encephalopathy (CTE) is a neurodegenerative disease thought to be caused, at least in part, by repetitive brain trauma, including concussive and subconcussive injuries. It is thought to result in executive dysfunction, memory impairment, depression and suicidality, apathy, poor impulse control, and eventually dementia. Beyond repetitive brain trauma, the risk factors for CTE remain unknown. CTE is neuropathologically characterized by aggregation and accumulation of hyperphosphorylated tau and TDP-43. Recent postmortem findings indicate that CTE may affect a broader population than was initially conceptualized, particularly contact sport athletes and those with a history of military combat. Given the large population that could potentially be affected, CTE may represent an important issue in public health. Although there has been greater public awareness brought to the condition in recent years, there are still many research questions that remain. Thus far, CTE can only be diagnosed post-mortem. Current research efforts are focused on the creation of clinical diagnostic criteria, finding objective biomarkers for CTE, and understanding the additional risk factors and underlying mechanism that causes the disease. This review examines research to date and suggests future directions worthy of exploration.
Starting Page	244
Ending Page	254
Page Count	11
File Format	PDF
ISSN	19317557
Journal	Brain Imaging and Behavior
Volume Number	6
Issue Number	2
e-ISSN	19317565
Language	English
Publisher	Springer-Verlag
Publisher Date	2012-05-03
Publisher Place	New York
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Chronic traumatic encephalopathy Traumatic brain injury Dementia Concussion Tauopathy Dementia pugilistica Psychiatry Neurosciences Neuropsychology Neuroradiology
Content Type	Text
Resource Type	Article
Subject	Neurology Radiology, Nuclear Medicine and Imaging Cognitive Neuroscience Behavioral Neuroscience Neurology (clinical) Cellular and Molecular Neuroscience Psychiatry and Mental Health

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