NDLI: Three approaches to investigating functional compromise to the default mode network after traumatic axonal injury

Content Provider	Springer Nature Link
Author	Arenivas, Ana Diaz Arrastia, Ramon Spence, Jeffrey Cullum, C. Munro Krishnan, Kamini Bosworth, Christopher Culver, Carlee Kennard, Beth Marquez de la Plata, Carlos
Copyright Year	2012
Abstract	The default mode network (DMN) is a reliably elicited functional neural network with potential clinical implications. Its discriminant and prognostic utility following traumatic axonal injury (TAI) have not been previously investigated. The present study used three approaches to analyze DMN functional connectedness, including a whole-brain analysis [A1], network-specific analysis [A2], and between-node (edge) analysis [A3]. The purpose was to identify the utility of each method in distinguishing between healthy and brain-injured individuals, and determine whether observed differences have clinical significance. Resting-state fMRI was acquired from 25 patients with TAI and 17 healthy controls. Patients were scanned 6–11 months post-injury, and functional and neurocognitive outcomes were assessed the same day. Using all three approaches, TAI subjects revealed significantly weaker functional connectivity (FC) than controls, and binary logistic regressions demonstrated all three approaches have discriminant value. Clinical outcomes were not correlated with FC using any approach. Results suggest that compromise to the functional connectedness of the DMN after TAI can be identified using resting-state FC; however, the degree of functional compromise to this network, as measured in this study, may not have clinical implications in chronic TAI.
Starting Page	407
Ending Page	419
Page Count	13
File Format	PDF
ISSN	19317557
Journal	Brain Imaging and Behavior
Volume Number	8
Issue Number	3
e-ISSN	19317565
Language	English
Publisher	Springer US
Publisher Date	2012-07-31
Publisher Place	Boston
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Default mode network Functional connectivity TBI Biomarker Outcome Traumatic axonal injury Neurosciences Neuroradiology Neuropsychology Psychiatry
Content Type	Text
Resource Type	Article
Subject	Neurology Radiology, Nuclear Medicine and Imaging Cognitive Neuroscience Behavioral Neuroscience Neurology (clinical) Cellular and Molecular Neuroscience Psychiatry and Mental Health

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