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| Content Provider | Springer Nature Link |
|---|---|
| Author | Yu, Min Wang, Xing xiang Zhang, Fu rong Shang, Yun peng Du, Yu xi Chen, Hong juan Chen, Jun zhu |
| Copyright Year | 2007 |
| Abstract | Idiopathic pulmonary arterial hypertension (IPAH) is a rare disease of unknown etiology. The exact pathogenesis of pulmonary arterial hypertension is still not well known. In the past decades, many protein molecules have been found to be involved in the development of IPAH. With proteomic techniques, profiling of human plasma proteome becomes more feasible in searching for disease-related markers. In present study, we showed the protein expression profiles of the serum of IPAH and healthy controls after depleting a few high-abundant proteins in serum. Thirteen spots had changed significantly in IPAH compared with healthy controls and were identified by LC-MS/MS. Alpha-1-antitrypsin and vitronectin were down-regulated in IPAH and may be valuable candidates for further explorations of their roles in the development of IPAH. |
| Starting Page | 221 |
| Ending Page | 227 |
| Page Count | 7 |
| File Format | |
| ISSN | 16731581 |
| Journal | Journal of Zhejiang University SCIENCE B |
| Volume Number | 8 |
| Issue Number | 4 |
| e-ISSN | 18621783 |
| Language | English |
| Publisher | Zhejiang University Press |
| Publisher Date | 2007-01-01 |
| Publisher Place | Hangzhou |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Idiopathic pulmonary arterial hypertension Two-dimensional gel electrophoresis LC-MS/MS Biomedicine general |
| Content Type | Text |
| Resource Type | Article |
| Subject | Veterinary Medicine Biochemistry, Genetics and Molecular Biology Pharmacology, Toxicology and Pharmaceutics |
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