NDLI: Mechanisms governing the visco-elastic responses of living cells assessed by foam and tensegrity models

Content Provider	Springer Nature Link
Author	Cañadas, P. Laurent, V. M. Chabrand, P. Isabey, D. Wendling Mansuy, S.
Copyright Year	2003
Abstract	The visco-elastic properties of living cells, measured to date by various authors, vary considerably, depending on the experimental methods and/or on the theoretical models used. In the present study, two mechanisms thought to be involved in cellular visco-elastic responses were analysed, based on the idea that the cytoskeleton plays a fundamental role in cellular mechanical responses. For this purpose, the predictions of an open unit-cell model and a 30-element visco-elastic tensegrity model were tested, taking into consideration similar properties of the constitutive F-actin. The quantitative predictions of the time constant and viscosity modulus obtained by both models were compared with previously published experimental data obtained from living cells. The small viscosity modulus values (10$^{0}$–10$^{3}$ Pa.s) predicted by the tensegrity model may reflect the combined contributions of the spatially rearranged constitutive filaments and the internal tension to the overall cytoskeleton response to external loading. In contrast, the high viscosity modulus values (10$^{3}$–10$^{5}$ Pa.s) predicted by the unit-cell model may rather reflect the mechanical response of the cytoskeleton to the bending of the constitutive filaments and/or to the deformation of internal components. The present results suggest the existence of a close link between the overall visco-elastic response of micromanipulated cells and the underlying architecture.
Starting Page	733
Ending Page	739
Page Count	7
File Format	PDF
ISSN	01400118
Journal	Medical and Biological Engineering and Computing
Volume Number	41
Issue Number	6
e-ISSN	17410444
Language	English
Publisher	Springer-Verlag
Publisher Date	2003-01-01
Publisher Place	Berlin, Heidelberg
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Cell micromanipulation Structural viscosity Open unit-cell model Multimodular cytoskeleton Actin filaments Viscosity modulus Human Physiology Computer Applications Neurosciences Imaging Radiology Biomedical Engineering
Content Type	Text
Resource Type	Article
Subject	Biomedical Engineering Computer Science Applications

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