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| Content Provider | Springer Nature Link |
|---|---|
| Author | Ganea, Doina Gonzalez Rey, Elena Delgado, Mario |
| Copyright Year | 2006 |
| Abstract | Vasoactive intestinal peptide (VIP), a well-known immunoregulatory neuropeptide, affects both innate and adaptive immunity, and acts as a major anti-inflammatory factor in animal models of autoimmune diseases. VIP down-regulates the innate immune response by inhibiting the release of proinflammatory cytokines, chemokines, and nitric oxide by activated macrophages, microglia, and dendritic cells. VIP affects the adaptive immune response by reducing the costimulatory capacity of antigen-presenting cells, and by preferentially inducing Th$_{2}$-type responses. This is accomplished through preferential Th$_{2}$ differentiation, enhanced survival of Th$_{2}$ effectors, and the induction of Th$_{2}$-attracting chemokines. Recently, we discovered a novel mechanism for the immunosuppressive effect of VIP that involves the generation of antigen-specific regulatory T cells (Treg) through the induction of tolerogenic dendritic cells (tDC). In this work, we review the VIP-induced Treg generation both in vivo and in vitro, and the use of VIP-generated Treg in two models of autoimmunity, i.e., collagen-induced arthritis and experimental autoimmune encephalomyelitis, and in bone marrow transplantation as related to graft-versus-host disease and the graft-versus-leukemia response. |
| Starting Page | 400 |
| Ending Page | 409 |
| Page Count | 10 |
| File Format | |
| ISSN | 15571890 |
| Journal | Journal of Neuroimmune Pharmacology |
| Volume Number | 1 |
| Issue Number | 4 |
| e-ISSN | 15571904 |
| Language | English |
| Publisher | Kluwer Academic Publishers-Plenum Publishers |
| Publisher Date | 2006-10-10 |
| Publisher Place | New York |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | neuropeptides vasoactive intestinal peptide tolerogenic dendritic cells regulatory T cells experimental autoimmune encephalomyelitis collagen-induced arthritis bone marrow transplantation Cell Biology Virology Pharmacology/Toxicology Immunology Neurosciences |
| Content Type | Text |
| Resource Type | Article |
| Subject | Neuroscience Immunology and Allergy Pharmacology Immunology |
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