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Cooperative mechanisms of thin filament activation and their contribution to the myocardial contractile function: Assessment in a mathematical model

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Cooperative mechanisms of thin filament activation and their contribution to the myocardial contractile function: Assessment in a mathematical model

Content Provider	Springer Nature Link
Author	Katsnelson, L. B. Sulman, T. B. Solovyova, O. E. Markhasin, V. S.
Copyright Year	2009
Abstract	A mathematical model was used for comparative analysis of the contribution to the myocardial mechanical activity of two potentially possible variants of the cooperative influence of myosin cross-bridges on calcium activation of sarcomere actin filaments. One of these variants implies that the cooperative action of the cross-bridge on the affinity of troponin C for calcium is localized within the functional group A$_{7}$TmTn (seven adjacent globular actin monomers, tropomyosin, and one troponin complex TnC + TnI + TnT) where this bridge is attached. The second variant is based on the assumption that cross-bridges may influence the troponin C affinity for calcium also in neighboring A$_{7}$TmTn groups (and the closer the group is positioned relative to the bridge, the stronger is the influence on the CaTnC complex affinity in this group). The contribution of each of these two variants to the active mechanical behavior of the cardiac muscle in the contraction-relaxation cycle was assessed. It turned out that adequate simulation of the muscle mechanical activity is provided only by the second variant. Thus, the results of modeling argue in favor of the existence of just this variant of cooperativity.
Starting Page	39
Ending Page	46
Page Count	8
File Format	PDF
ISSN	00063509
Journal	Biophysics
Volume Number	54
Issue Number	1
e-ISSN	15556654
Language	English
Publisher	SP MAIK Nauka/Interperiodica
Publisher Date	2009-06-09
Publisher Place	Dordrecht
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	calcium regulation of muscle contraction mechanics of active myocardium load-dependent relaxation Biophysics/Biomedical Physics
Content Type	Text
Resource Type	Article
Subject	Biophysics

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