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Thin filament flexibility and its role in muscle contraction

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Thin filament flexibility and its role in muscle contraction

Content Provider	Springer Nature Link
Author	Skubiszak, L.
Copyright Year	2006
Abstract	Contemporary experimental methods do not allow unequivocal determination of molecular structural events during muscle contraction. To analyze existing contradictions, an original computer program has been developed. This program reconstructs the hexagonal lattice of a sarcomere for different states of muscle and finds the most realistic structure by comparing the calculated Fourier spectrum with the actual diffraction pattern. Previously, the new approach allowed reconstructing the actual structure of a myosin filament from mammalian striated muscle ( http://zope.ibib.waw.pl/pspk ). In this work, the thin filament is reconstructed for three states: relaxed, activated, and contracting. The good fit between the calculated Fourier spectra and the actual diffraction patterns taken from the literature suggests that the thin filament owing to its flexibility may play an active role in muscle contraction, as myosin cross-bridges do.
Starting Page	692
Ending Page	700
Page Count	9
File Format	PDF
ISSN	00063509
Journal	Biophysics
Volume Number	51
Issue Number	5
e-ISSN	15556654
Language	English
Publisher	Nauka/Interperiodica
Publisher Date	2006-01-01
Publisher Place	Moscow
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	muscle contraction mechanism thin filament structure actin computer modeling Biophysics/Biomedical Physics
Content Type	Text
Resource Type	Article
Subject	Biophysics

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