NDLI: DNA sequencing using specific long-range interaction between macromolecules

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DNA sequencing using specific long-range interaction between macromolecules

Content Provider	Springer Nature Link
Author	Namiot, V. A. Anashkina, A. A. Filatov, I. V. Tumanyan, V. G. Esipova, N. G.
Copyright Year	2012
Abstract	On the basis of the theory of specific long-range interaction between long molecules, an approach has been elaborated for «fast reading» of nucleotide sequences in one DNA molecule. First, a stretching force is applied to the molecule that causes its unwinding from B-form to S-form. Then, the molecule is placed in the stretched state on a support. After this, the electrostatic potential is estimated in a space along the DNA filament. The information obtained is sufficient for deducing the nucleotide sequence. Another approach to the «reading» of information reduces to measurement of the deformation of filament elements induced by the electric field from the electrode that stretches the filament by an alternating current applied.
Starting Page	716
Ending Page	721
Page Count	6
File Format	PDF
ISSN	00063509
Journal	Biophysics
Volume Number	57
Issue Number	6
e-ISSN	15556654
Language	English
Publisher	SP MAIK Nauka/Interperiodica
Publisher Date	2013-02-26
Publisher Place	Dordrecht
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	DNA sequencing long distance interactions electrostatic potential Fourier transform bonded water Biophysics and Biological Physics
Content Type	Text
Resource Type	Article
Subject	Biophysics

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