NDLI: Labelling of a pyrazole derivative with $^{131}$I and investigation of its radiopharmaceutical potential

Content Provider	Springer Nature Link
Author	Kurtdede, Esra Bildirici, Ishak Enginar, Hüseyin Sener, Ahmet
Copyright Year	2013
Abstract	We investigated the radiolabeling efficiency, in vitro stability, and biodistribution of radioactive iodine ($^{131}$I)-labeled 4-benzoyl-1-(4-carboxyphenyl)-5-phenyl-1H-pyrazole-3-carboxylic acid (P3CA). A quality-control study of the labeled substance ($^{131}$I-P3CA) was conducted using electrophoresis and radio thin-layer chromatography (RTLC). Biodistribution studies were undertaken in 9 female albino Wistar rats. Rats were killed at various times (15, 60 and 180 min), their organs removed, and percentage of injected dose per gram (ID%/g) values calculated. The labeling yield of P3CA was 97.08%±0.80%. The maximum uptake of $^{131}$I-P3CA was seen in the lungs, stomach and spleen at 15 min. The uptake of labeled compound decreased over time in the lungs, whereas that in the stomach decreased. These data suggest that $^{131}$I-P3CA had high binding efficiency, high uptake in the lung, and sufficient stability to be used in diagnostic studies.
Starting Page	2964
Ending Page	2969
Page Count	6
File Format	PDF
ISSN	10016538
Journal	Chinese Science Bulletin
Volume Number	58
Issue Number	24
e-ISSN	18619541
Language	English
Publisher	Springer Berlin Heidelberg
Publisher Date	2013-05-18
Publisher Place	Berlin, Heidelberg
Access Restriction	Subscribed
Subject Keyword	pyrazole derivative lungs $^{131}$I biodistribution rat Science Life Sciences Physics Chemistry/Food Science Earth Sciences Engineering
Content Type	Text
Resource Type	Article
Subject	Multidisciplinary

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