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| Content Provider | Springer Nature Link |
|---|---|
| Author | Zhang, Zhihua Zhang, Yong Shi, Baochen Deng, Wei Zhao, Yi Chen, Runsheng |
| Copyright Year | 2004 |
| Abstract | The 5′/3′ UTRs of mRNA are crucial in translational regulation, and several serious diseases are believed to be associated with abnormal splicing of these parts of the mRNA sequence. In this work a novel method which uses sequence alignment database searching for detecting chimeric 5′3′ UTRs with cross-chromosomal splicing is reported. Eight highly credible instances of cross-chromosomal splicing have been found using this method, representing additional confirmation of the existence of cross-chromosomal splicing events provided by bioinformatics tools. Since no conserved motif has been found in any of the eight instances, and at the same time current prediction algorithms produce only trivial secondary structures at the “splicing sites”, it is not possible to identify any specific signal leading to the splicing. |
| Starting Page | 1051 |
| Ending Page | 1054 |
| Page Count | 4 |
| File Format | |
| ISSN | 10016538 |
| Journal | Chinese Science Bulletin |
| Volume Number | 49 |
| Issue Number | 10 |
| e-ISSN | 18619541 |
| Language | English |
| Publisher | Science in China Press |
| Publisher Date | 2004-01-01 |
| Publisher Place | Beijing |
| Access Restriction | Subscribed |
| Subject Keyword | 5′/3′ UTRs mRNA trans-splicing chromosomal translocations chimeric Science Life Sciences Physics Chemistry/Food Science Earth Sciences Engineering |
| Content Type | Text |
| Resource Type | Article |
| Subject | Multidisciplinary |
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