NDLI: Construction of fine SNP haplotypes and haplotype blocks in 5 genes in the centromere of chromosome 15 in Chinese Han subjects

Content Provider	Springer Nature Link
Author	Huang, Weijun Li, Caixia Chen, Suqin Sun, Jiandong Zhou, Yan Fang, Jiqian Wang, Yiming
Copyright Year	2004
Abstract	Recent advances have shown that the majority of the nucleotide variation in human genome is single nucleotide polymorphisms (SNPs). Using SNPs each chromosome can be divided into different haplotype blocks, and there are limited common haplotypes in each block. This provides a powerful approach for whole genome scan for disease-associated genes/variants. However, most data available today are based on the large-scale genomic analyses, data concerning individual genes for fine mapping with high density SNPs are relatively lacking. We have sequenced 7 genes and their flanking regions, identified 34 novel SNPs, constructed high density SNP haplotypes and haplotype blocks in 5 genes in the centromeric region of chromosome 15 in 100 Chinese Han subjects. Our results show that there is a great heterogeneity in the haplotypes and haplotype block structures within and between these genes, which are in close physical proximity. Data obtained in this study provide a useful tool for candidate gene approach at the fine scale for identifying disease contributing variants in the genes/regions.
Starting Page	1044
Ending Page	1051
Page Count	8
File Format	PDF
ISSN	10016538
Journal	Chinese Science Bulletin
Volume Number	49
Issue Number	10
e-ISSN	18619541
Language	English
Publisher	Science in China Press
Publisher Date	2004-01-01
Publisher Place	Beijing
Access Restriction	Subscribed
Subject Keyword	haplotype haplotype-block SNP genome centromeric genes in chromosome 15 Science Life Sciences Physics Chemistry/Food Science Earth Sciences Engineering
Content Type	Text
Resource Type	Article
Subject	Multidisciplinary

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