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| Content Provider | Springer Nature Link |
|---|---|
| Author | Chen, YuQi Cao, Jie Zhu, HongYan Cui, SiSi Wang, AQin Qian, ZhiYu Gu, YueQing |
| Copyright Year | 2013 |
| Abstract | In this study, an amphiphilic copolymer folate-succinyl-methionine-chitosan-octyl (FSMCO) was successfully synthesized step by step for self-assembling polymeric micelles. The copolymers formed micelle-like nanoparticles by their amphiphilic characteristics and structures were examined by UV-Vis absorption and Fourier transform spectroscopy. The sizes of blank and ICG derivative-loaded micelles measured by dynamic light scattering were about 170 and 140 nm, respectively, which were spherical in shape with an average zeta potential of −10 mV. Further studies on the stability showed that the micellar solutions maintain their sizes at room temperature for 1 month without distinct aggregation or dissociation. ICG derivative was much better photostable after being entrapped by the new carrier. The prepared FSMCO micelles displayed a good drug loading content (11.7%), entrapment efficiency (66.5%) and sustained release rate for the model drug fluorescein. The copolymers demonstrated weeny cytotoxicity toward Bel-7402, L02 and A549 cells when incubated for 2 d. Ligands modified micelles endowed preferable cell targeting capability and beautiful cell inhibition of HCPT-FSMCO on Bel-7402 tumor cells. This kind of polymeric micelles may be a promising nanovehicle in delivering near-infrared dyes for tumors imaging and chemotherapeutic drugs for cancer therapeutics. |
| Starting Page | 2379 |
| Ending Page | 2386 |
| Page Count | 8 |
| File Format | |
| ISSN | 10016538 |
| Journal | Chinese Science Bulletin |
| Volume Number | 58 |
| Issue Number | 19 |
| e-ISSN | 18619541 |
| Language | English |
| Publisher | Springer Berlin Heidelberg |
| Publisher Date | 2013-03-07 |
| Publisher Place | Berlin, Heidelberg |
| Access Restriction | Subscribed |
| Subject Keyword | folate methionine chitosan micelles ICG derivative Science Life Sciences Physics Chemistry/Food Science Earth Sciences Engineering |
| Content Type | Text |
| Resource Type | Article |
| Subject | Multidisciplinary |
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