NDLI: Seizures dynamics in a neural field model of cortical-thalamic circuitry

Content Provider	Springer Nature Link
Author	Zhang, HongHui Zheng, YanHong Su, JianZhong Xiao, PengCheng
Copyright Year	2017
Abstract	The focus of this study is to explore the mechanisms during seizure behavior using a physiologically motivated by corticothalamic circuity. The model is based on the assumption that, the inhibitory projects from thalamus reticular nucleus (TRN) to specific relay nuclei (SRN) are mediated by GABA$_{A}$ and GABA$_{B}$ receptors which react different time scales in synaptic transmission. Secondly, we include the effects of slow modulation on the threshold current of TRN population that were found to generate bursting behavior. Our model can reproduce healthy and pathological dynamics including wake, spindle, deep sleep, and also seizure states. In addition, contour maps are used to explore the transition of different activity states. It is worthy to point out seizure duration is significantly affected by a time-varying delay as illustrated in our numerical simulation. Finally, a reduced model ignoring the cerebral cortex mass can also capture the feature of spike wave discharge as generated in the full network.
Starting Page	974
Ending Page	984
Page Count	11
File Format	PDF
ISSN	16747321
Journal	Science in China Series E: Technological Sciences
Volume Number	60
Issue Number	7
e-ISSN	18691900
Language	English
Publisher	Science China Press
Publisher Date	2017-06-21
Publisher Place	Beijing
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	seizure spike wave neural field modeling corticothalamic Engineering
Content Type	Text
Resource Type	Article
Subject	Engineering Materials Science

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1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
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