Please wait, while we are loading the content...
Please wait, while we are loading the content...
| Content Provider | Springer Nature Link |
|---|---|
| Author | Tang, Jun Zhang, Juan Ma, Jun Zhang, GuoYing Yang, XianQing |
| Copyright Year | 2016 |
| Abstract | It has been revealed experimentally that astrocytes can participate in synaptic transmission by modulating and responding to the release of neurotransmitters with calcium elevations. Researches suggest that seizure-like discharges (SDs) or seizure-like firings (SFs) in neurons, characterizing neurological disorder, may arise locally in restricted areas (focal area) and then propagate throughout the brain. But the underlying mechanism remains unclear. To study the possible role astrocytes playing in the SDs propagation, we construct a minimal neuron-astrocyte network model by connecting a neurons chain and an astrocytes chain. The focal area is modelled by an IP3 reservoir which provides persistent IP$_{3}$ out-flux. The study suggests that calcium wave propagation in astrocytes determines the propagation of SDs in the connected neurons. On the other hand, SDs in neurons allows the calcium wave propagates longer distance in the astrocytes, which suggests the mutually cooperating of astrocytes and neurons in accomplishing SD propagation. Furthermore, once SDs propagate and occupy the neuron network, it could not be terminated by recovery of the focal area. The results may imply that treatment of brain disorders should not only focus on local area but the whole neuron network. |
| Starting Page | 1011 |
| Ending Page | 1018 |
| Page Count | 8 |
| File Format | |
| ISSN | 16747321 |
| Journal | Science in China Series E: Technological Sciences |
| Volume Number | 60 |
| Issue Number | 7 |
| e-ISSN | 18691900 |
| Language | English |
| Publisher | Science China Press |
| Publisher Date | 2016-12-30 |
| Publisher Place | Beijing |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | astrocyte calcium wave seizure-like firing Engineering |
| Content Type | Text |
| Resource Type | Article |
| Subject | Engineering Materials Science |
National Digital Library of India (NDLI) is a virtual repository of learning resources which is not just a repository with search/browse facilities but provides a host of services for the learner community. It is sponsored and mentored by Ministry of Education, Government of India, through its National Mission on Education through Information and Communication Technology (NMEICT). Filtered and federated searching is employed to facilitate focused searching so that learners can find the right resource with least effort and in minimum time. NDLI provides user group-specific services such as Examination Preparatory for School and College students and job aspirants. Services for Researchers and general learners are also provided. NDLI is designed to hold content of any language and provides interface support for 10 most widely used Indian languages. It is built to provide support for all academic levels including researchers and life-long learners, all disciplines, all popular forms of access devices and differently-abled learners. It is designed to enable people to learn and prepare from best practices from all over the world and to facilitate researchers to perform inter-linked exploration from multiple sources. It is developed, operated and maintained from Indian Institute of Technology Kharagpur.
Learn more about this project from here.
NDLI is a conglomeration of freely available or institutionally contributed or donated or publisher managed contents. Almost all these contents are hosted and accessed from respective sources. The responsibility for authenticity, relevance, completeness, accuracy, reliability and suitability of these contents rests with the respective organization and NDLI has no responsibility or liability for these. Every effort is made to keep the NDLI portal up and running smoothly unless there are some unavoidable technical issues.
Ministry of Education, through its National Mission on Education through Information and Communication Technology (NMEICT), has sponsored and funded the National Digital Library of India (NDLI) project.
| Sl. | Authority | Responsibilities | Communication Details |
|---|---|---|---|
| 1 | Ministry of Education (GoI), Department of Higher Education |
Sanctioning Authority | https://www.education.gov.in/ict-initiatives |
| 2 | Indian Institute of Technology Kharagpur | Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project | https://www.iitkgp.ac.in |
| 3 | National Digital Library of India Office, Indian Institute of Technology Kharagpur | The administrative and infrastructural headquarters of the project | Dr. B. Sutradhar bsutra@ndl.gov.in |
| 4 | Project PI / Joint PI | Principal Investigator and Joint Principal Investigators of the project |
Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon |
| 5 | Website/Portal (Helpdesk) | Queries regarding NDLI and its services | support@ndl.gov.in |
| 6 | Contents and Copyright Issues | Queries related to content curation and copyright issues | content@ndl.gov.in |
| 7 | National Digital Library of India Club (NDLI Club) | Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach | clubsupport@ndl.gov.in |
| 8 | Digital Preservation Centre (DPC) | Assistance with digitizing and archiving copyright-free printed books | dpc@ndl.gov.in |
| 9 | IDR Setup or Support | Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops | idr@ndl.gov.in |
|
Loading...
|