NDLI: Involvement of monoaminergic systems in anxiolytic and antidepressive activities of the standardized extract of Cocos nucifera L.

Content Provider	Springer Nature Link
Author	Lima, Eliane Brito Cortez Sousa, Caren Nádia Soares Meneses, Lucas Nascimento e Silva Pereira, Yuri Freitas Matos, Natália Castelo Branco Freitas, Rayanne Brito Lima, Nycole Brito Cortez Patrocínio, Mael Cláudio Azevedo Leal, Luzia Kalyne Almeida Moreira Viana, Glauce Socorro Barros Vasconcelos, Silvânia Maria Mendes
Copyright Year	2016
Abstract	Extracts from the husk fiber of Cocos nucifera are used in folk medicine, but their actions on the central nervous system have not been studied. Here, the anxiolytic and antidepressant effects of the standardized hydroalcoholic extract of C. nucifera husk fiber (HECN) were evaluated. Male Swiss mice were treated with HECN (50, 100, or 200 mg/kg) 60 min before experiments involving the plus maze test, hole-board test, tail suspension test, and forced swimming test (FST). HECN was administered orally (p.o.) in acute and repeated-dose treatments. The forced swimming test was performed with dopaminergic and noradrenergic antagonists, as well as a serotonin release inhibitor. Administration of HECN in the FST after intraperitoneal (i.p.) pretreatment of mice with sulpiride (50 mg/kg), prazosin (1 mg/kg), or p-chlorophenylalanine (PCPA, 100 mg/kg) caused the actions of these three agents to be reversed. However, this effect was not observed after pretreating the animals with SCH23390 (15 µg/kg, i.p.) or yohimbine (1 mg/kg, i.p.) The dose chosen for HECN was 100 mg/kg, p.o., which increased the number of entries as well as the permanence in the open arms of the maze after acute and repeated doses. In both the forced swimming and the tail suspension tests, the same dose decreased the time spent immobile but did not disturb locomotor activity in an open-field test. The anxiolytic effect of HECN appears to be related to the GABAergic system, while its antidepressant effect depends upon its interaction with the serotoninergic, noradrenergic (α1 receptors), and dopaminergic (D2 dopamine receptors) systems.
Starting Page	227
Ending Page	237
Page Count	11
File Format	PDF
ISSN	13403443
Journal	Journal of Natural Medicines
Volume Number	71
Issue Number	1
e-ISSN	18610293
Language	English
Publisher	Springer Japan
Publisher Date	2016-10-21
Publisher Place	Tokyo
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Anxiolytic Antidepressive C. nucifera L. Hydroalcoholic extract of C. nucifera husk fiber Pharmacology/Toxicology Plant Sciences Complementary & Alternative Medicine Medicinal Chemistry Pharmacy
Content Type	Text
Resource Type	Article
Subject	Organic Chemistry Drug Discovery Molecular Medicine Complementary and Alternative Medicine Pharmaceutical Science

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