NDLI: Green tea cultivar ‘Benifuuki’ potentiates split vaccine-induced immunoglobulin A production

Content Provider	Springer Nature Link
Author	Won, Yeong Seon Kumazoe, Motofumi Takamatsu, Kanako Shida, Yuki Soda, Saki Okada, Kenji Okamoto, Takehisa Tachibana, Hirofumi
Copyright Year	2016
Abstract	Influenza is a widespread disease caused by infection with the influenza virus. Vaccination is considered to be the main countermeasure against influenza. A split vaccine is widely used to avoid severe adverse events, and it induces strong humoral immunity. However, the split vaccine alone cannot elicit mucosal immunity, including IgA production, and its preventative effects are limited. Here, we show that the green tea cultivar ‘Benifuuki’ extract enhanced the effect of a split vaccine on mucosal immunity. The frequency of IgA$^{+}$ cells was increased in lung and Peyer’s patch that received Benifuuki diet. Secretion of hemagglutinin-specific mucosal IgA, which is closely linked to the prevention of viral infection, was significantly increased in the bronchoalveolar lavage fluid of split vaccine-immunized BALB/c mice that were administered green tea Benifuuki extract. Our findings suggest that Benifuuki intake enhanced the effects of the split vaccine on mucosal immunity.
Starting Page	68
Ending Page	75
Page Count	8
File Format	PDF
ISSN	13403443
Journal	Journal of Natural Medicines
Volume Number	71
Issue Number	1
e-ISSN	18610293
Language	English
Publisher	Springer Japan
Publisher Date	2016-08-03
Publisher Place	Tokyo
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Benifuuki Green tea Influenza virus Methylated EGCG Split vaccine Virus-specific IgA Pharmacology/Toxicology Plant Sciences Complementary & Alternative Medicine Medicinal Chemistry Pharmacy
Content Type	Text
Resource Type	Article
Subject	Organic Chemistry Drug Discovery Molecular Medicine Complementary and Alternative Medicine Pharmaceutical Science

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