NDLI: Toxicity of different forms of graphene in a chicken embryo model

Content Provider	Springer Nature Link
Author	Szmidt, Maciej Sawosz, Ewa Urbańska, Kaja Jaworski, Sławomir Kutwin, Marta Hotowy, Anna Wierzbicki, Mateusz Grodzik, Marta Lipińska, Ludwika Chwalibog, André
Copyright Year	2016
Abstract	In the present work, the toxicity of three forms of graphene: pristine graphene (pG), graphene oxide (GO), and reduced graphene oxide (rGO) was investigated using a chicken embryo model. Fertilized chicken eggs were divided into the control group and groups administered with pG, GO, and rGO, in concentrations of 50, 500, and 5000 μg/ml. The experimental solutions were injected in ovo into the eggs, and at day 18 of incubation, the embryo survival, body and organ weights, the ultrastructure of liver samples, and the concentration of 8-hydroxy-2′-deoxyguanosine (8-OHdG) in the livers were measured. Survival of embryos decreased significantly after treatment with all types of graphene, but not in a dose-dependent manner. The body weights were only slightly affected by the highest doses of graphene, while the organ weights were not different among treatment groups. In all experimental groups, atypical hepatocyte ultrastructure and mitochondrial damage were observed. The concentration of the marker of DNA damage 8-OHdG in the liver significantly decreased after pG and rGO treatments. Further in vivo studies with different animal models are necessary to clarify the level of toxicity of different types of graphene and to estimate the concentrations appropriate to evaluate their biomedical applications and environmental hazard.
Starting Page	19940
Ending Page	19948
Page Count	9
File Format	PDF
ISSN	09441344
Journal	Environmental Science and Pollution Research
Volume Number	23
Issue Number	19
e-ISSN	16147499
Language	English
Publisher	Springer Berlin Heidelberg
Publisher Date	2016-07-19
Publisher Place	Berlin, Heidelberg
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Graphene Graphene oxide Chicken embryo Toxicity Liver Tem DNA damage Environment Environmental Chemistry Ecotoxicology Environmental Health Atmospheric Protection/Air Quality Control/Air Pollution Waste Water Technology Water Pollution Control Water Management Aquatic Pollution
Content Type	Text
Resource Type	Article
Subject	Environmental Chemistry Health, Toxicology and Mutagenesis Pollution Medicine

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