NDLI: Perfluorooctanoic acid (PFOA) acts as a tumor promoter on Syrian hamster embryo (SHE) cells

Content Provider	Springer Nature Link
Author	Jacquet, N. Maire, M. A. Rast, C. Bonnard, M. Vasseur, P.
Copyright Year	2012
Abstract	Perfluorooctane sulfonate (PFOS) (C$_{8}$F$_{17}$SO$_{3}$) and perfluorooctanoic acid (PFOA) (C$_{8}$HF$_{15}$O$_{2}$) are synthetic chemicals widely used in industrial applications for their hydrophobic and oleophobic properties. They are persistent, bioaccumulative, and toxic to mammalian species. Their widespread distribution on earth and contamination of human serum raised concerns about long-term side effects. They are suspected to be carcinogenic through a nongenotoxic mode of action, a mechanism supported by recent findings that PFOS induced cell transformation but no genotoxicity in Syrian hamster embryo (SHE) cells. In the present study, we evaluated carcinogenic potential of PFOA using the cell transformation assay on SHE cells. The chemical was applied alone or in combination with a nontransformant concentration of benzo[a]pyrene (BaP, 0.4 μM) in order to detect PFOA ability to act as tumor initiator or tumor promoter. The results showed that PFOA tested alone in the range 3.7 × 10$^{−5}$ to 300 μM did not induce SHE cell transformation frequency in a 7-day treatment. On the other side, the combination BaP/PFOA induced cell transformation at all PFOA concentrations tested, which revealed synergistic effects. No genotoxicity of PFOA on SHE cells was detected using the comet assay after 5 and 24 h of exposure. No significant increase in DNA breakage was found in BaP-initiated cells exposed to PFOA in a 7-day treatment. The whole results showed that PFOA acts as a tumor promoter and a nongenotoxic carcinogen. Cell transformation in initiated cells was observed at concentrations equivalent to the ones found in human serum of nonoccupationally and occupationally exposed populations. An involvement of PFOA in increased incidence of cancer recorded in occupationally exposed population cannot be ruled out.
Starting Page	2537
Ending Page	2549
Page Count	13
File Format	PDF
ISSN	09441344
Journal	Environmental Science and Pollution Research
Volume Number	19
Issue Number	7
e-ISSN	16147499
Language	English
Publisher	Springer-Verlag
Publisher Date	2012-08-31
Publisher Place	Berlin, Heidelberg
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Perfluorooctanoic acid (PFOA) Carcinogenicity Genotoxicity Cell transformation assay (CTA) Perfluorooctane sulfonate (PFOS) Syrian hamster embryo (SHE) cells Environment Analytical Chemistry Atmospheric Protection/Air Quality Control/Air Pollution Waste Water Technology Water Pollution Control Water Management Aquatic Pollution Industrial Pollution Prevention
Content Type	Text
Resource Type	Article
Subject	Environmental Chemistry Health, Toxicology and Mutagenesis Pollution Medicine

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in

Perfluorooctanoic Acid (PFOA) and Perfluorooctane Sulfonate (PFOS)

Perfluorooctane Sulfonate (PFOS) and Perfluorooctanoic Acid (PFOA) in Water Environment of Singapore

Investigation of the Effects of Perfluorooctanoic Acid (PFOA) and Perfluorooctane Sulfonate (PFOS) on Apoptosis and Cell Cycle in a Zebrafish (Danio rerio) Liver Cell Line

Provisional Health Advisories for Perfluorooctanoic Acid (PFOA) and Perfluorooctane Sulfonate (PFOS)

Determination of perfluorooctanoic acid (PFOA) and perfluorooctane sulfonate (PFOS) in water samples of Langat River

Exposure to perfluorinated compounds: in vitro study on thyroid cells

Pollution pathways and release estimation of perfluorooctane sulfonate (PFOS) and perfluorooctanoic acid (PFOA) in central and eastern China.

Research association of perfluorooctanoic acid (pfoa) and perfluorooctane sulfonate (pfos) with uric acid among adults with elevated community exposure to pfoa.

PFOS and PFOA in paired urine and blood from general adults and pregnant women: assessment of urinary elimination

Perfluorooctanoic acid (PFOA) acts as a tumor promoter on Syrian hamster embryo (SHE) cells

Similar Documents

Perfluorooctanoic Acid (PFOA) and Perfluorooctane Sulfonate (PFOS)

Perfluorooctane Sulfonate (PFOS) and Perfluorooctanoic Acid (PFOA) in Water Environment of Singapore

Investigation of the Effects of Perfluorooctanoic Acid (PFOA) and Perfluorooctane Sulfonate (PFOS) on Apoptosis and Cell Cycle in a Zebrafish (Danio rerio) Liver Cell Line

Provisional Health Advisories for Perfluorooctanoic Acid (PFOA) and Perfluorooctane Sulfonate (PFOS)

Determination of perfluorooctanoic acid (PFOA) and perfluorooctane sulfonate (PFOS) in water samples of Langat River

Exposure to perfluorinated compounds: in vitro study on thyroid cells

Pollution pathways and release estimation of perfluorooctane sulfonate (PFOS) and perfluorooctanoic acid (PFOA) in central and eastern China.

Research association of perfluorooctanoic acid (pfoa) and perfluorooctane sulfonate (pfos) with uric acid among adults with elevated community exposure to pfoa.

PFOS and PFOA in paired urine and blood from general adults and pregnant women: assessment of urinary elimination

Perfluorooctanoic acid (PFOA) acts as a tumor promoter on Syrian hamster embryo (SHE) cells