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| Content Provider | Springer Nature Link |
|---|---|
| Author | Ben Salem, Intidhar Boussabbeh, Manel Helali, Sabeh Abid Essefi, Salwa Bacha, Hassen |
| Copyright Year | 2015 |
| Abstract | Zearalenone (ZEN) is a mycotoxin from Fusarium species commonly found in many food commodities and known to cause reproductive disorders. Several studies have shown that ZEN is hematotoxic and hepatotoxic and causes several alterations of immunological parameters. In the present study, we aimed to evaluate the protective effect of Crocin (CRO), a natural carotenoid, against ZEN-induced toxicity in both renal and hepatic tissues of Balb/c mice. We demonstrated that ZEN (40 mg/kg body weight (b.w.)) induced oxidative stress in both kidney and liver as monitored by measuring the malondialdehyde (MDA) level, the protein carbonyl generation, the catalase and superoxide dismutase activity, and the expression of the heat shock proteins (Hsp70). However, combined treatment of ZEN with different doses of CRO (50, 100, and 250 mg/kg b.w.) significantly reduced ZEN-induced alterations in all tested oxidative stress markers. It could be concluded that CRO was effective in the protection against ZEN-induced toxicity in the liver and kidney of Balb/c mice. |
| Starting Page | 19069 |
| Ending Page | 19076 |
| Page Count | 8 |
| File Format | |
| ISSN | 09441344 |
| Journal | Environmental Science and Pollution Research |
| Volume Number | 22 |
| Issue Number | 23 |
| e-ISSN | 16147499 |
| Language | English |
| Publisher | Springer Berlin Heidelberg |
| Publisher Date | 2015-08-02 |
| Publisher Place | Berlin, Heidelberg |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Zearalenone Crocin Oxidative stress Liver Kidney Environment Environmental Chemistry Ecotoxicology Environmental Health Atmospheric Protection/Air Quality Control/Air Pollution Waste Water Technology Water Pollution Control Water Management Aquatic Pollution |
| Content Type | Text |
| Resource Type | Article |
| Subject | Environmental Chemistry Health, Toxicology and Mutagenesis Pollution Medicine |
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