NDLI: Photo-Fenton and Fenton-like processes for the treatment of the antineoplastic drug 5-fluorouracil under simulated solar radiation

Content Provider	Springer Nature Link
Author	Koltsakidou, Α. Antopoulou, M. Sykiotou, M. Εvgenidou, Ε. Konstantiu, I. Lambropoulou, D.A.
Copyright Year	2016
Abstract	In the present study, photo-Fenton and Fenton-like processes were investigated for the degradation and mineralization of the antineoplastic drug 5-fluorouracil (5-FU). For the optimization of photo-Fenton treatment under simulated solar light (SSL) radiation, the effects of several operating parameters (i.e., 5-FU concentration, Fe$^{3+}$, and oxidant concentration) on the treatment efficiency were studied. According to the results, SSL/[Fe(C$_{2}$Ο$_{4}$)$_{3}$]$^{3−}$/Η$_{2}$Ο$_{2}$ process was the most efficient, since faster degradation of 5-FU and higher mineralization percentages were achieved. All the applied processes followed quite similar transformation routes which include defluorination-hydroxylation as well as pyrimidine ring opening, as demonstrated by the transformation products identified by high resolution mass spectrometry analysis. The toxicity of the treated solutions was evaluated using the Microtox assay. In general, low toxicity was recorded for the initial solution and the solution at the end of the photocatalytic treatment, while an increase in the overall toxicity was observed only at the first stages of SSL/Fe$^{3+}$/Η$_{2}$Ο$_{2}$ and SSL/Fe$^{3+}$/S$_{2}$O$_{8}$ $^{2−}$ processes.
Starting Page	4791
Ending Page	4800
Page Count	10
File Format	PDF
ISSN	09441344
Journal	Environmental Science and Pollution Research
Volume Number	24
Issue Number	5
e-ISSN	16147499
Language	English
Publisher	Springer Berlin Heidelberg
Publisher Date	2016-12-16
Publisher Place	Berlin, Heidelberg
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	5-fluorouracil Pharmaceuticals Photo-Fenton Fenton-like processes AOPs Toxicity Transformation products Environment Environmental Chemistry Ecotoxicology Environmental Health Atmospheric Protection/Air Quality Control/Air Pollution Waste Water Technology Water Pollution Control Water Management Aquatic Pollution
Content Type	Text
Resource Type	Article
Subject	Environmental Chemistry Health, Toxicology and Mutagenesis Pollution Medicine

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