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| Content Provider | Springer Nature Link |
|---|---|
| Author | Dornelles, Eduardo B. Goncalves, Bayard D. Schott, Karen Lilian Barbisan, Fernanda Unfer, Tais C. Glanzner, Werner G. Machado, Alencar K. Cadona, Francine C. Azzolin, Veronica Farina Monta, Marco Aurélio Echart Griner, John Cruz, Ivana B. M. |
| Copyright Year | 2016 |
| Abstract | Technological advancement has increasingly exposed humans to magnetic fields (MFs). However, more insights are necessary into the potential toxicity of MF exposure as a result of genetic variations related to oxidative metabolism. Therefore, the following study has assessed an in vitro cytotoxic effect of static magnetic field (SMF) (5 mT) on cells with Val16Ala polymorphism (AA, VA, and VV) in the manganese superoxide dismutase gene. Homozygous Val16Ala-superoxide dismutase 2 (SOD2) genotypes present oxidative imbalance that is associated with risk to several chronic degenerative diseases (VV produces less efficient and AA more efficient SOD2 enzyme). Blood samples from healthy adult subject carriers with different Val16Ala-SOD2 genotypes were obtained and exposed to MF at different times (0, 1, 3, 6 h). The cytotoxic effect as well as oxidative stress was evaluated after incubation of 24 h at 37 °C. In addition, apoptosis induction has been analyzed by flow cytometry as well as Bcl-2-associated X protein (BAX), B-cell lymphoma 2 (BCL-2), and caspases 8 and 3 gene expression. SMF cytotoxic effect has been observed in AA cells at all times of exposure, whereas AV cells presented higher mortality only after 6 h of exposure at SMF. Higher apoptosis induction has been observed in AA cells when compared to VV and AV cells. These results suggest a toxicogenetic SMF effect related to an imbalance in SOD2 activity. |
| Starting Page | 5078 |
| Ending Page | 5088 |
| Page Count | 11 |
| File Format | |
| ISSN | 09441344 |
| Journal | Environmental Science and Pollution Research |
| Volume Number | 24 |
| Issue Number | 5 |
| e-ISSN | 16147499 |
| Language | English |
| Publisher | Springer Berlin Heidelberg |
| Publisher Date | 2016-12-21 |
| Publisher Place | Berlin, Heidelberg |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | PBMC Genotype Oxidative stress SOD2 Magnetic field Environment Environmental Chemistry Ecotoxicology Environmental Health Atmospheric Protection/Air Quality Control/Air Pollution Waste Water Technology Water Pollution Control Water Management Aquatic Pollution |
| Content Type | Text |
| Resource Type | Article |
| Subject | Environmental Chemistry Health, Toxicology and Mutagenesis Pollution Medicine |
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