NDLI: Molecular epizootiology of infectious bursal disease (IBD) in Korea

Content Provider	Springer Nature Link
Author	Jeon, Woo Jin Choi, Kang Seuk Lee, Dong Woo Lee, Eun Kyoung Cha, Sang Ho Cho, Sun Hee Kwon, Jun Hun Yoon, Yeo sung Kim, Sun Joong Kim, Jae Hong Kwon, Hyuk Joon
Copyright Year	2009
Abstract	We conducted a molecular epizootiological study of infectious bursal disease (IBD) in Korea by analyzing 85 IBD viruses (IBDVs) obtained from vaccinated or unvaccinated flocks between 1980 and 2007. Phylogenetic analysis of the partial nucleotide sequence of the hypervariable region of the VP2 gene (nucleotides 661–1020) and pathogenicity tests revealed more genetic and phenotypic diversity of IBDV in Korea than has been reported previously. We showed that very virulent IBDVs (vvIBDVs) were already present in Korea in 1986. Moreover, vvIBDVs were repeatedly detected in Korean poultry that had been vaccinated, which casts doubt on the IBD vaccine programs. We also identified novel putative antigenic variant (AV)-like IBDV isolates on the basis of their antigenic indices and the presence of amino acid changes (P222S or P222T-A321D) that are known to affect the antigenicity of VP2. These observations suggest that future studies examining the efficacy of conventional vaccines against atrophy of the bursa of Fabricius and vvIBDV shedding may be useful. Moreover, it will be of interest to determine the prevalence of putative Korean antigenic variants and whether these strains exert immunosuppressive effects in vaccinated birds.
Starting Page	342
Ending Page	351
Page Count	10
File Format	PDF
ISSN	09208569
Journal	Virus Genes
Volume Number	39
Issue Number	3
e-ISSN	1572994X
Language	English
Publisher	Springer US
Publisher Date	2009-09-01
Publisher Place	Boston
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Very virulent infectious bursal disease virus Molecular epizootiology VP2 Antigenic variant Vaccine Plant Sciences Virology Medical Microbiology
Content Type	Text
Resource Type	Article
Subject	Virology Genetics Medicine Molecular Biology

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