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| Content Provider | Springer Nature Link |
|---|---|
| Author | Cao, Ming Mei Li, Gang Ren, Hao Pan, Wei Zhao, Ping Qi, Zhong Tian |
| Copyright Year | 2009 |
| Abstract | The GB virus C/hepatitis G virus (GBV-C/HGV) is a Flaviviridae member that despite its nonpathogenicity, has become of great interest given that it could inhibit the replication of the human immunodeficiency virus (HIV). Therefore, a better knowledge of the viral protein E2 has become our aim. In this study, a GBV-C model cell system (HuhEG) which expressing a fusion protein of the GBV-C E2 protein and enhanced green fluorescent protein (EGFP) stably was established. And the expression of these proteins was silenced effectively by the two E2 gene-specific siRNAs and an EGFP gene-specific siRNA. This inhibition is sequence-specific and extensive (90%). This HuhEG/specific siRNAs system can provide an approach for investigating the association between GBV-C E2 and HIV replication, which may be of potential value in the development of novel prophylactic or therapeutic agents for HIV infection. |
| Starting Page | 324 |
| Ending Page | 329 |
| Page Count | 6 |
| File Format | |
| ISSN | 09208569 |
| Journal | Virus Genes |
| Volume Number | 39 |
| Issue Number | 3 |
| e-ISSN | 1572994X |
| Language | English |
| Publisher | Springer US |
| Publisher Date | 2009-10-03 |
| Publisher Place | Boston |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | RNA interference Small interfering RNA GBV-C Gene expression Plant Sciences Virology Medical Microbiology |
| Content Type | Text |
| Resource Type | Article |
| Subject | Virology Genetics Medicine Molecular Biology |
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