NDLI: High-resolution analysis of CpG methylation and in vivo protein–DNA interactions at the alternative Epstein-Barr virus latency promoters Qp and Cp in the nasopharyngeal carcinoma cell line C666-1

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High-resolution analysis of CpG methylation and in vivo protein–DNA interactions at the alternative Epstein-Barr virus latency promoters Qp and Cp in the nasopharyngeal carcinoma cell line C666-1

Content Provider	Springer Nature Link
Author	Bakos, Agnes Banati, Ferenc Koroknai, Anita Takacs, Maria Salamon, Daniel Minarovits Kormuta, Susanna Schwarzmann, Fritz Wolf, Hans Niller, Hans Helmut Minarovits, Jas
Copyright Year	2007
Abstract	Transcripts for the Epstein-Barr virus (EBV) encoded nuclear antigens (EBNAs) are initiated at alternative promoters (Wp, Cp, for EBNA 1–6 transcripts and Qp, for EBNA 1 transcripts only) located in the BamHI W, C or Q fragment of the viral genome. To understand the host-cell dependent expression of EBNAs in EBV-associated tumors (lymphomas and carcinomas) and in vitro transformed cell lines, it is necessary to analyse the regulatory mechanisms governing the activity of the alternative promoters of EBNA transcripts. Such studies focused mainly on lymphoid cell lines carrying latent EBV genomes, due to the lack of EBV-associated carcinoma cell lines maintaining latent EBV genomes during cultivation in tissue culture. We took advantage of the unique nasopharyngeal carcinoma cell line, C666-1, harboring EBV genomes, and undertook a detailed analysis of CpG methylation patterns and in vivo protein-DNA interactions at the latency promoters Qp and Cp. We found that the active, unmethylated Qp was marked with strong footprints of cellular transcription factors and the viral protein EBNA 1. In contrast, we could not detect binding of relevant transcription factors to the methylated, silent Cp. We concluded that the epigenetic marks at Qp and Cp in C666-1 cells of epithelial origin resemble those of group I Burkitt’s lymphoma cell lines.
Starting Page	195
Ending Page	202
Page Count	8
File Format	PDF
ISSN	09208569
Journal	Virus Genes
Volume Number	35
Issue Number	2
e-ISSN	1572994X
Language	English
Publisher	Springer US
Publisher Date	2007-05-18
Publisher Place	Boston
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Epstein-Barr virus DNA methylation Protein–DNA interaction Latency promoter Nasopharyngeal carcinoma Plant Sciences Virology Medical Microbiology
Content Type	Text
Resource Type	Article
Subject	Virology Genetics Medicine Molecular Biology

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Protein-DNA Binding and CpG Methylation at Nucleotide Resolution of Latency-Associated Promoters Qp, Cp, and LMP1p of Epstein-Barr Virus

Latency type-specific distribution of epigenetic marks at the alternative promoters Cp and Qp of Epstein-Barr virus.

CpG-Methylation Regulates a Class of Epstein-Barr Virus Promoters

Hypermethylation of the interferon regulatory factor 5 promoter in Epstein-Barr virus-associated gastric carcinoma

Detection of methylation status of Epstein‐Barr virus DNA C promoter in the diagnosis of nasopharyngeal carcinoma

High-resolution Methylation Analysis and In Vivo Protein–DNA Binding at the Promoter of the Viral Oncogene LMP2A in B Cell Lines Carrying Latent Epstein–Barr Virus Genomes

Nasopharyngeal carcinoma cell line (C666-1) consistently harbouring Epstein-Barr virus

Host cell-determined methylation of specific epstein-barr virus promoters regulates the choice between distinct viral latency programs (1997).

Epstein-Barr virus (EBV)-host cell interactions: an epigenetic dialogue?

High-resolution analysis of CpG methylation and in vivo protein–DNA interactions at the alternative Epstein-Barr virus latency promoters Qp and Cp in the nasopharyngeal carcinoma cell line C666-1

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