NDLI: A comparative analysis of insertional effects in genetically engineered plants: considerations for pre-market assessments

Content Provider	Springer Nature Link
Author	Schnell, Jaimie Steele, Marina Bean, Jordan Neuspiel, Margaret Girard, Cécile Dormann, Nataliya Pearson, Cindy Savoie, Annie Bourbonnière, Luc Macdonald, Philip
Copyright Year	2014
Abstract	During genetic engineering, DNA is inserted into a plant’s genome, and such insertions are often accompanied by the insertion of additional DNA, deletions and/or rearrangements. These genetic changes are collectively known as insertional effects, and they have the potential to give rise to unintended traits in plants. In addition, there are many other genetic changes that occur in plants both spontaneously and as a result of conventional breeding practices. Genetic changes similar to insertional effects occur in plants, namely as a result of the movement of transposable elements, the repair of double-strand breaks by non-homologous end-joining, and the intracellular transfer of organelle DNA. Based on this similarity, insertional effects should present a similar level of risk as these other genetic changes in plants, and it is within the context of these genetic changes that insertional effects must be considered. Increased familiarity with genetic engineering techniques and advances in molecular analysis techniques have provided us with a greater understanding of the nature and impact of genetic changes in plants, and this can be used to refine pre-market assessments of genetically engineered plants and food and feeds derived from genetically engineered plants.
Starting Page	1
Ending Page	17
Page Count	17
File Format	PDF
ISSN	09628819
Journal	Transgenic Research
Volume Number	24
Issue Number	1
e-ISSN	15739368
Language	English
Publisher	Springer International Publishing
Publisher Date	2014-10-26
Publisher Place	Cham
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Insertional effects Novel trait Unintended trait Genetic engineering Conventional breeding Pre-market assessment Molecular Medicine Plant Genetics & Genomics Animal Genetics and Genomics Plant Sciences Transgenics
Content Type	Text
Resource Type	Article
Subject	Genetics Animal Science and Zoology Biotechnology Agronomy and Crop Science

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1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
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3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
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