NDLI: Inducible, reversible hair loss in transgenic mice

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Transgenic Research : Volume 11, Issue 2, April 2002

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Inducible, reversible hair loss in transgenic mice

Content Provider	Springer Nature Link
Author	Chen, Jingshan Kelz, Max B. Zeng, Guoqi Steffen, Cathy Shockett, Penny E. Terwilliger, Gordon Schatz, David G. Nestler, Eric J.
Copyright Year	2002
Abstract	Telogen effluvium is a common type of hair loss. Although the morphological changes associated with telogen effluvium have been well characterized, the underlying molecular mechanisms remain unknown, and no animal models have been developed. We report here that inducible transgenic mice expressing high levels of the transcription factor, tTA (tetracycline transactivator), plus a reporter luciferase gene, show a reversible hair loss phenotype. Skin of these mice exhibits an increase in the number of hair follicles at the telogen phase, but a decreased number of follicles at the anagen phase. These changes resemble skin pathology seen in patients with telogen effluvium, which suggests that the inducible transgenic mice may be useful as a model for this disorder. Moreover, since overexpression of several other transgenes failed to cause skin pathology, the present findings also indicate types of molecular abnormalities that may cause reversible hair loss.
Starting Page	241
Ending Page	247
Page Count	7
File Format	PDF
ISSN	09628819
Journal	Transgenic Research
Volume Number	11
Issue Number	3
e-ISSN	15739368
Language	English
Publisher	Kluwer Academic Publishers-Plenum Publishers
Publisher Date	2002-01-01
Publisher Place	New York
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Human Genetics Plant Sciences Animal Anatomy / Morphology / Histology
Content Type	Text
Resource Type	Article
Subject	Genetics Animal Science and Zoology Biotechnology Agronomy and Crop Science

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