NDLI: Actions and interactions of growth hormone and insulin-like growth factor-II: body and organ growth of transgenic mice

Please wait, while we are loading the content...

Report on the Inaugural Meeting of the Laboratory Animal Science Association's Specialist Section on Transgenic Animals, The Wellcome Institute -- 27th September 1996

Normotensive blood pressure in mice with a disrupted renin Ren-1d gene

Germ-free and barrier-raised TGFβ1-deficient mice have similar inflammatory lesions

Phenotypic and genotypic stability of multiple lines of transgenic pigs expressing recombinant human protein C

Actions and interactions of growth hormone and insulin-like growth factor-II: body and organ growth of transgenic mice

A comparison of the germline potential of differently aged ES cell lines and their transfected descendants

Transient expression of anthocyanin genes in barley epidermal cells: potential for use in evaluation of disease response genes

Transgenic tobacco plants expressing the putative movement protein of tomato spotted wilt tospovirus exhibit aberrations in growth and appearance

Transgenic Research : Volume 6, Issue 2, March 1997

Transgenic Research : Volume 6, Issue 1, January 1997

Actions and interactions of growth hormone and insulin-like growth factor-II: body and organ growth of transgenic mice

Content Provider	Springer Nature Link
Author	Blackburn, Alexia Schmitt, Andrea Schmidt, Peter Wanke, Rudiger Hermanns, Walter Brem, Gottfried Wolf, Eckhard
Copyright Year	1997
Abstract	To characterize long-term actions and interactions of growth hormone (GH) and insulin-like growth factor-II (IGF-II) on postnatal body and organ growth, hemizygous phosphoenolpyruvate carboxykinase (PEPCK)-human IGF-II transgenic mice were crossed with hemizygous PEPCK-bovine GH transgenic mice. The latter are characterized by two-fold increased serum levels of IGF-I and exhibit markedly increased body, skeletal and organ growth. Four different genetic groups were obtained: mice harbouring the IGF-II transgene (I), the bGH transgene (B), or both transgenes (IB), and non- transgenic controls (C). These groups of mice have previously been studied for circulating IGF-I levels (Wolf et al., 1995a), whereas the present study deals with body and organ growth. Growth curves (week 3 to 12) were estimated by regression with linear and quadratic components of age on body weight and exhibited significantly (p < 0.001) greater linear coefficients in B and IB than in I and C mice. The linear coefficients of male I and C mice were significantly (p < 0.001) greater than those of their female counterparts, whereas this sex-related difference was absent in the bGH transgenic groups. The weights of internal organs as well as the weights of abdominal fat, skin and carcass were recorded from 3.5- to 8- month-old mice. In addition, organ weight-to-body weight-ratios (relative organ weights) were calculated. Except for the weight of abdominal fat, absolute organ weights were as a rule significantly greater in B and IB than in I and C mice. IGF-II overproduction as a tendency increased the weights of kidneys, adrenal glands, pancreas and uterus both in the absence and presence of the bGH transgene. Analysis of relative organ weights demonstrated significant (p < 0.05) effects of elevated IGF- II on the relative growth of kidneys (males and females) and adrenal glands (females), confirming our previous report on organ growth of PEPCK-IGF-II transgenic mice. In females, IGF-II and GH overproduction were additive in stimulating the growth of spleen and uterus, providing evidence for tissue-specific postnatal growth promoting effects by IGF-II in the presence of elevated IGF-I
Starting Page	213
Ending Page	222
Page Count	10
File Format	PDF
ISSN	09628819
Journal	Transgenic Research
Volume Number	6
Issue Number	3
e-ISSN	15739368
Language	English
Publisher	Kluwer Academic Publishers-Plenum Publishers
Publisher Date	1997-01-01
Publisher Place	New York
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Human Genetics Plant Sciences Animal Anatomy / Morphology / Histology
Content Type	Text
Resource Type	Article
Subject	Genetics Animal Science and Zoology Biotechnology Agronomy and Crop Science

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in

Overexpression of Growth Hormone Affects Alternatively Spliced IGF-I mRNA Expression in oMt1a-oGH Transgenic Mice

Expression of the Bovine Growth Hormone Alters the Root Morphology in Transgenic Tobacco Plants

Stable Production of Human Insulin-like Growth Factor 1 (IGF-1) in the Milk of Hemi- and Homozygous Transgenic Rabbits Over Several Generations

Inducible, reversible hair loss in transgenic mice

Expression of the human insulin gene in the gastric G cells of transgenic mice

Transgenic Animal Welfare

Expression of a Novel Piscine Growth Hormone Gene Results in Growth Enhancement in Transgenic Tilapia (Oreochromis Niloticus)

Expression of Lysostaphin in Milk of Transgenic Mice Affects the Growth of Neonates

Ubiquitous expression of goat cyclin T1 in transgenic mice

Actions and interactions of growth hormone and insulin-like growth factor-II: body and organ growth of transgenic mice

Similar Documents

Overexpression of Growth Hormone Affects Alternatively Spliced IGF-I mRNA Expression in oMt1a-oGH Transgenic Mice

Expression of the Bovine Growth Hormone Alters the Root Morphology in Transgenic Tobacco Plants

Stable Production of Human Insulin-like Growth Factor 1 (IGF-1) in the Milk of Hemi- and Homozygous Transgenic Rabbits Over Several Generations

Inducible, reversible hair loss in transgenic mice

Expression of the human insulin gene in the gastric G cells of transgenic mice

Transgenic Animal Welfare

Expression of a Novel Piscine Growth Hormone Gene Results in Growth Enhancement in Transgenic Tilapia (Oreochromis Niloticus)

Expression of Lysostaphin in Milk of Transgenic Mice Affects the Growth of Neonates

Ubiquitous expression of goat cyclin T1 in transgenic mice

Actions and interactions of growth hormone and insulin-like growth factor-II: body and organ growth of transgenic mice