NDLI: Silencing of six susceptibility genes results in potato late blight resistance

Content Provider	Springer Nature Link
Author	Sun, Kaile Wolters, Anne Marie A. Vossen, Jack H. Rouwet, Maarten E. Loonen, Annelies E. H. M. Jacobsen, Evert Visser, Richard G. F. Bai, Yuling
Copyright Year	2016
Abstract	Phytophthora infestans, the causal agent of late blight, is a major threat to commercial potato production worldwide. Significant costs are required for crop protection to secure yield. Many dominant genes for resistance (R-genes) to potato late blight have been identified, and some of these R-genes have been applied in potato breeding. However, the P. infestans population rapidly accumulates new virulent strains that render R-genes ineffective. Here we introduce a new class of resistance which is based on the loss-of-function of a susceptibility gene (S-gene) encoding a product exploited by pathogens during infection and colonization. Impaired S-genes primarily result in recessive resistance traits in contrast to recognition-based resistance that is governed by dominant R-genes. In Arabidopsis thaliana, many S-genes have been detected in screens of mutant populations. In the present study, we selected 11 A. thaliana S-genes and silenced orthologous genes in the potato cultivar Desiree, which is highly susceptible to late blight. The silencing of five genes resulted in complete resistance to the P. infestans isolate Pic99189, and the silencing of a sixth S-gene resulted in reduced susceptibility. The application of S-genes to potato breeding for resistance to late blight is further discussed.
Starting Page	731
Ending Page	742
Page Count	12
File Format	PDF
ISSN	09628819
Journal	Transgenic Research
Volume Number	25
Issue Number	5
e-ISSN	15739368
Language	English
Publisher	Springer International Publishing
Publisher Date	2016-05-28
Publisher Place	Cham
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Late blight Potato Resistance RNAi Susceptibility gene Animal Genetics and Genomics Plant Genetics & Genomics Transgenics Biomedical Engineering/Biotechnology Genetic Engineering Molecular Medicine
Content Type	Text
Resource Type	Article
Subject	Genetics Animal Science and Zoology Biotechnology Agronomy and Crop Science

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