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| Content Provider | Springer Nature Link |
|---|---|
| Author | Akhmadishina, L. Z. Korytina, G. F. Victorova, T. V. |
| Copyright Year | 2011 |
| Abstract | The contribution of the polymorphic markers of cytochrome P450 genes to respiratory diseases caused by smoking and occupational factors has been assessed. For this purpose, PCR-RFLP analysis of the CYP1B1 (rs1056836, 4326C > G), CYP2F1 (rs11399890, c.14_15insC), CYP2J2 (rs890293, -76G > T), and CYP2S1 (rs34971233, 13106C > T and rs338583, 13255A > G) gene polymorphisms has been performed. The analysis has shown that CYP1B1 (rs1056836, 4326C > G) and CYP2F1 (rs11399890, c.14_15insC) polymorphisms may contribute to the development of occupational chronic bronchitis. The proportion of CYP1B1*1*3 heterozygotes in the group of patients with occupational chronic bronchitis is considerably greater than in the group of healthy workers (69.16% versus 53.29%; χ$^{2}$ = 5.94, p = 0.02, p $_{cur}$ = 0.04, OR = 1.97, the 95% CI is 1.13–3.42). Patients with occupational chronic bronchitis and healthy workers significantly differed from each other in the CYP2F1 genotypes frequency distribution (rs11399890, c.14_15insC) (χ$^{2}$ = 6.18, d.f. = 2, p = 0.05). CYP2F1 wild type/ins heterozygous genotype frequency is higher in healthy workers (36.08%) than in patients (22.22%) (χ$^{2}$ = 5.48, p = 0.02, p $_{cur}$ = 0.04, OR = 0.51, the 95% CI is 0.28–0.90). No association has been found between the CYP2J2 (rs890293, −76G > T) or CYP2S1 (rs34971233, 13106C > T, and rs338583, 13255A > G) gene polymorphisms and respiratory diseases. |
| Starting Page | 1248 |
| Ending Page | 1255 |
| Page Count | 8 |
| File Format | |
| ISSN | 10227954 |
| Journal | Russian Journal of Genetics |
| Volume Number | 47 |
| Issue Number | 10 |
| e-ISSN | 16083369 |
| Language | English |
| Publisher | SP MAIK Nauka/Interperiodica |
| Publisher Date | 2011-10-08 |
| Publisher Place | Dordrecht |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Microbial Genetics and Genomics Animal Genetics and Genomics Human Genetics |
| Content Type | Text |
| Resource Type | Article |
| Subject | Genetics |
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