NDLI: Immunization with a synthetic fragment 155–164 of neurotrophin receptor p75 prevents memory loss and decreases beta-amyloid level in mice with experimentally induced Alzheimer’s disease

Content Provider	Springer Nature Link
Author	Volpina, O. M. Medvinskaya, N. I. Kamynina, A. V. Zaporozhskaya, Y. V. Aleksandrova, I. J. Koroev, D. O. Samokhin, A. N. Volkova, T. D. Arseniev, A. S. Bobkova, N. V.
Copyright Year	2014
Abstract	Neurotoxic beta-amyloid peptide plays an important role in the pathology of Alzheimer’s disease. In aggregated form it binds to several proteins on the surface of the brain cells leading to their death. p75 receptor involved in supporting of cell balance is one of the targets for toxic beta-amyloid. We proposed that induction of antibodies against potential binding sites of p75 with beta-amyloid can be a promising approach towards development of new anti-Alzheimer’s disease treatment. Four potentially immunoactive fragments of p75 were chosen and chemically synthesized. Investigation of immunoprotective effect of the peptide fragments carried out in mice with experimentally induced form of Alzheimer’s disease helped to reveal two fragments effectively preserving murine memory from impairment. Results obtained by ELISA biochemical analysis showed that only immunization with fragment p75 155–164 led to significant decrease in beta-amyloid level in the brain of the experimental mice. Thus, immunization with both fragments of p75 receptor pro-vides a new insight into anti-Alzheimer’s disease drug design.
Starting Page	417
Ending Page	422
Page Count	6
File Format	PDF
ISSN	10681620
Journal	Russian Journal of Bioorganic Chemistry
Volume Number	40
Issue Number	4
e-ISSN	1608330X
Language	English
Publisher	Pleiades Publishing
Publisher Date	2014-07-25
Publisher Place	Moscow
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Alzheimer’s disease neurotrophin receptor p75 beta-amyloid synthetic peptides antibodies Biochemistry Bioorganic Chemistry Organic Chemistry Biomedicine general
Content Type	Text
Resource Type	Article
Subject	Organic Chemistry Biochemistry

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