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| Content Provider | Springer Nature Link |
|---|---|
| Author | Koroev, D. O. Volpina, O. M. Volkova, T. D. Kamynina, A. V. Filatova, M. P. Balasanyants, S. M. Samokhin, A. N. Bobkova, N. V. |
| Copyright Year | 2017 |
| Abstract | Six synthetic peptides overlapping a fragment 60–76 of the receptor for advanced glycation end products (RAGE) were studied on a protective effect on spatial memory of animals in the experimental model of Alzheimer’s disease. It was shown that only a peptide corresponding to the fragment 60–70 of RAGE exhibits a therapeutic activity. Intranasal administration of this peptide into bulbectomized mice, which develop neurodegenerative features of the Alzheimer type, completely protects animal memory. Thus, it was found that the N-terminal region (60–70) within the peptide sequence 60–76 of RAGE is responsible for the revealed protective effect. The synthetic peptide RAGE-(60–70) could be the basis for the development of a new drug for the treatment of Alzheimer’s disease. |
| Starting Page | 150 |
| Ending Page | 154 |
| Page Count | 5 |
| File Format | |
| ISSN | 10681620 |
| Journal | Russian Journal of Bioorganic Chemistry |
| Volume Number | 43 |
| Issue Number | 2 |
| e-ISSN | 1608330X |
| Language | English |
| Publisher | Pleiades Publishing |
| Publisher Date | 2017-04-19 |
| Publisher Place | Moscow |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Alzheimer’s disease receptor for advanced glycation end products beta-amyloid synthetic peptides intranasal administration Biochemistry Bioorganic Chemistry Organic Chemistry Biomedicine |
| Content Type | Text |
| Resource Type | Article |
| Subject | Organic Chemistry Biochemistry |
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