NDLI: A Non-digestible Fraction of the Common Bean (Phaseolus vulgaris L.) Induces Cell Cycle Arrest and Apoptosis During Early Carcinogenesis

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A Non-digestible Fraction of the Common Bean (Phaseolus vulgaris L.) Induces Cell Cycle Arrest and Apoptosis During Early Carcinogenesis

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A Non-digestible Fraction of the Common Bean (Phaseolus vulgaris L.) Induces Cell Cycle Arrest and Apoptosis During Early Carcinogenesis

Content Provider	Springer Nature Link
Author	Feregri Perez, Ana Angelica Piñol Felis, Carmen Gomez Arbones, Xavier Guevara González, Ramón G. Campos Vega, Rocio Acosta Gallegos, Jorge Loarca Piña, Guadalupe
Copyright Year	2014
Abstract	We have previously demonstrated that the non-digestible fraction (NDF) from common cooked beans (P. vulgaris L., cv Negro 8025) inhibits azoxymethane (AOM)-induced colon cancer and influences the expression of genes involved in the induction of apoptosis and cell cycle arrest through the action of butyrate. The objective of this study was to identify cell cycle alterations and morphological changes induced by treatment with AOM and to examine the formation of colonic aberrant crypt foci (ACF) in male Sprague Dawley rats fed with these beans. Rats were fed control diets upon arrival and were randomly placed into four groups after one week of acclimatization: control, NDF (intragastric administration), NDF + AOM and AOM. Rats treated with NDF + AOM exhibited a significantly lower number of total colonic ACF with a notable increase in the number of cells present in the G$_{1}$ phase (83.14 %); a decreased proliferation index was observed in the NDF + AOM group when compared to AOM group. NDF + AOM also displayed a higher number of apoptotic cells compared to AOM group. NDF of cooked common beans inhibited colon carcinogenesis at an early stage by inducing cell cycle arrest of colon cells and morphological changes linked to apoptosis, thus confirming previous results obtained with gene expression studies.
Starting Page	248
Ending Page	254
Page Count	7
File Format	PDF
ISSN	09219668
Journal	Plant Foods for Human Nutrition
Volume Number	69
Issue Number	3
e-ISSN	15739104
Language	English
Publisher	Springer US
Publisher Date	2014-06-21
Publisher Place	New York
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Non-digestible fraction Phaseolus vulgaris L. Flow cytometry Apoptosis Aberrant crypt foci Food Science Chemistry/Food Science Nutrition Ecology Plant Physiology
Content Type	Text
Resource Type	Article
Subject	Chemistry Food Science

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