NDLI: Can phytochemicals be a bridge to develop new radioprotective agents?

Content Provider	Springer Nature Link
Author	Aprotosoaie, Ana Clara Trifan, Adriana Gille, Elvira Petreus, Tudor Bordeianu, Gabriela Miron, Anca
Copyright Year	2014
Abstract	Various phytochemicals, mainly phenolic derivatives, have been screened for their radioprotective properties. This review summarizes the current knowledge in radioprotection using plant bioactive compounds with emphasis on two promising compounds, curcumin and genistein. Free radical scavenging abilities, maintaining cellular antioxidant status, modulation of DNA repair or prevention of DNA damages and anti-inflammatory activity are the main mechanisms involved in radioprotection exerted by phytochemicals. The chemical structure–activity relationship, the limits of existing research as well as the suggestions on further studies including clinical application are also discussed.
Starting Page	555
Ending Page	566
Page Count	12
File Format	PDF
ISSN	15687767
Journal	Phytochemistry Reviews
Volume Number	14
Issue Number	4
e-ISSN	1572980X
Language	English
Publisher	Springer Netherlands
Publisher Date	2014-09-07
Publisher Place	Dordrecht
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Curcumin Genistein Keap1/Nrf 2 pathway Free radicals scavenging Anticlastogenic Plant Sciences Plant Genetics & Genomics Biochemistry Organic Chemistry Chemistry/Food Science
Content Type	Text
Resource Type	Article
Subject	Plant Science Biotechnology

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Can phytochemicals be a bridge to develop new radioprotective agents?