NDLI: Chemical and bioactive diversities of the genera Stachybotrys and Memnoniella secondary metabolites

Content Provider	Springer Nature Link
Author	Wang, Anran Xu, Yaobo Gao, Yanxiu Huang, Qian Luo, Xie An, Hongmei Dong, Jinyan
Copyright Year	2014
Abstract	During the course of search for novel and bioactive molecules of microbial origin for drug development, Stachybotrys and Memnoniella fungi generally have been found to be a rich source of novel and bioactive secondary metabolites of great importance. Results of phylogenetic analyses were in agreement that the Memnoniella is paraphyletic to Stachybotrys. Interestingly, most Memnoniella spp. were found to produce the similar chemical substances. Up until now, almost 200 secondary metabolites belonging to diverse structural types of trichothecene, triprenyl phenol, diterpenoid, isochroman, polyketide, cochlioquinone and cyclic peptide have been discovered. Most of these fungal metabolites were reported to possess several interesting biological activities, such as disruption of the complement system, inhibition of TNF-α release, endothelin receptor antagonism, anti-influenza A virus, antimalarial, inhibition of avian myeloblastosis virus protease, cholesterol esterase, tyrosine kinase, farnesyl-protein transferase, squalene synthase and human heart chymase as well as stimulation of plasminogen, fibrinolysis, thrombolysis. This review summarizes the research on the isolation, structure elucidation, structural diversity, and bioactivities of the Stachybotrys and Memnoniella fungal secondary metabolites reported up to the year of 2014, and then highlights some bioactive compounds as well as their mechanisms of action and structure–activity relationships.
Starting Page	623
Ending Page	655
Page Count	33
File Format	PDF
ISSN	15687767
Journal	Phytochemistry Reviews
Volume Number	14
Issue Number	4
e-ISSN	1572980X
Language	English
Publisher	Springer Netherlands
Publisher Date	2014-05-25
Publisher Place	Dordrecht
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Bioactivities Diterpenoid Metabolites Stachybotrys and Memnoniella SMTPs Plant Sciences Plant Genetics & Genomics Biochemistry Organic Chemistry Chemistry/Food Science
Content Type	Text
Resource Type	Article
Subject	Plant Science Biotechnology

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