NDLI: Cultivation-independent approaches to investigate the chemistry of marine symbiotic bacteria

Content Provider	Springer Nature Link
Author	Uria, Agustinus Piel, Jörn
Copyright Year	2009
Abstract	Sessile marine animals like sponges, tunicates, and bryozoans are a rich source of bioactive natural products, many of which exhibit potent anticancer activities. However, most of these substances are available in very limited amounts only, which has prohibited further drug development. Recent evidence suggests that symbiotic bacteria might be the true producers of many animal-derived metabolites. In addition to revealing fascinating perspectives for research in marine chemical ecology, these findings suggest new solutions to the supply problem. Although most symbionts remain uncultivated, bacterial production systems might be created by isolating biosynthetic genes from marine metagenomes, and expressing them in culturable bacterial hosts. This review discusses cell-sorting, natural product visualization, and phylogenetic approaches to identify symbiotic producers. In addition, strategies to isolate genes and gene clusters from marine species consortia are described. These techniques have provided insights into the bacterial origin and biosynthesis of polyketides like the onnamides, swinholides, and bryostatins, of peptides including the patellamides, chlorinated dipeptides, and theopalauamide as well as of brominated biphenylethers.
Starting Page	401
Ending Page	414
Page Count	14
File Format	PDF
ISSN	15687767
Journal	Phytochemistry Reviews
Volume Number	8
Issue Number	2
e-ISSN	1572980X
Language	English
Publisher	Springer Netherlands
Publisher Date	2009-04-04
Publisher Place	Dordrecht
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Marine natural products Metagenomics Symbiosis Uncultivated bacteria Gene cloning Sponges Tunicates Bryozoans Biosynthesis Chemistry/Food Science Organic Chemistry Biochemistry Plant Genetics & Genomics Plant Sciences
Content Type	Text
Resource Type	Article
Subject	Plant Science Biotechnology

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in

Antitumor potential of natural products from Mediterranean ascidians

Marine natural products as inhibitors of hypoxic signaling in tumors

Capturing Natural Product Biosynthetic Pathways from Uncultivated Symbiotic Bacteria of Marine Sponges Through Metagenome Mining: A Mini-Review

Terpenoids from Marine Organisms: Unique Structures and their Pharmacological Potential

Metagenomic approaches to exploit the biotechnological potential of the microbial consortia of marine sponges

Biosynthesis in marine sponges: the radiolabelling strikes back

Bioactive natural products from marine sponges and fungal endophytes

Approaches to the total synthesis of biologically active natural products: studies directed towards bryostatins

Molecular cross-talk between sponge host and associated microbes

Cultivation-independent approaches to investigate the chemistry of marine symbiotic bacteria

Similar Documents

Antitumor potential of natural products from Mediterranean ascidians

Marine natural products as inhibitors of hypoxic signaling in tumors

Capturing Natural Product Biosynthetic Pathways from Uncultivated Symbiotic Bacteria of Marine Sponges Through Metagenome Mining: A Mini-Review

Terpenoids from Marine Organisms: Unique Structures and their Pharmacological Potential

Metagenomic approaches to exploit the biotechnological potential of the microbial consortia of marine sponges

Biosynthesis in marine sponges: the radiolabelling strikes back

Bioactive natural products from marine sponges and fungal endophytes

Approaches to the total synthesis of biologically active natural products: studies directed towards bryostatins

Molecular cross-talk between sponge host and associated microbes

Cultivation-independent approaches to investigate the chemistry of marine symbiotic bacteria