NDLI: Effect of Oropharyngeal Length in Drug Lung Delivery via Suspension Pressurized Metered Dose Inhalers

Content Provider	Springer Nature Link
Author	Ehtezazi, T. Allanson, D. R. Jenkinson, I. D. O'Callaghan, C.
Copyright Year	2006
Abstract	To determine the effect of the oropharyngeal length in adults on the lung dose of a suspension pressurized metered dose inhaler, and whether employing small volume spacers can alter this role.Depositions of Ventolin™ Evohaler™ (100) μg in the oropharyngeal models of two healthy adult subjects with 17.1 cm (short cast) and 19.9 cm (long cast) centerline lengths via three small volume spacers [two spacers with 3 cm effective length but one with 6.5 cm$^{2}$ (L3) and the other with 24.6 cm$^{2}$ (L3W) cross sections, and the Optimiser] were studied.Without using spacers, lung dose of the long cast (19.52 ± 2.32 μg, mean ± standard deviation) was significantly larger than that for the short cast (8.08 ± 1.01 μg, p < 0.006). However, using the L3 spacer with the short cast made the lung dose (18.59 ± 3.33 μg) similar to that for the long cast alone. Lung doses of the short cast (20.43 ± 1.42 μg) and the long cast (30.81 ± 1.84 μg) with the L3W spacer were similar to those with the L3 spacer. However, using the Optimiser spacer increased the lung dose for the short cast (22.27 ± 6.03 μg) and significantly for the long cast (35.61 ± 2.19 μg, p < 0.006) compared to those for the L3 spacer. Using spacers increased drug deposition in the oropharynx part of the short cast, and this reduced the lung dose compared to that for the long cast.The oropharyngeal length in adults may affect the lung dose via the pMDIs, which may not be eliminated by using small volume spacers.
Starting Page	1364
Ending Page	1372
Page Count	9
File Format	PDF
ISSN	07248741
Journal	Pharmaceutical Research
Volume Number	23
Issue Number	6
e-ISSN	1573904X
Language	English
Publisher	Springer-Verlag
Publisher Date	2006-05-26
Publisher Place	New York
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	oropharyngeal length orophryngeal models, the upper airway pressurized metered dose inhaler small volume spacers Pharmacology/Toxicology Pharmacy Biochemistry Medical Law Biomedical Engineering
Content Type	Text
Resource Type	Article
Subject	Organic Chemistry Pharmacology Molecular Medicine Pharmacology (medical) Biotechnology Pharmaceutical Science

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