NDLI: Influence of Air Flow on the Performance of a Dry Powder Inhaler Using Computational and Experimental Analyses

Content Provider	Springer Nature Link
Author	Coates, Matthew S. Chan, Hak Kim Fletcher, David F. Raper, Judy A.
Copyright Year	2005
Abstract	The aims of the study are to analyze the influence of air flow on the overall performance of a dry powder inhaler (Aerolizer$^{®}$) and to provide an initial quantification of the flow turbulence levels and particle impaction velocities that maximized the inhaler dispersion performance.Computational fluid dynamics (CFD) analysis of the flowfield in the Aerolizer$^{®}$, in conjunction with experimental dispersions of mannitol powder using a multistage liquid impinger, was used to determine how the inhaler dispersion performance varied as the device flow rate was increased.Both the powder dispersion and throat deposition were increased with air flow. The capsule retention was decreased with flow, whereas the device retention first increased then decreased with flow. The optimal inhaler performance was found at 65 l min$^{−1}$ showing a high fine particle fraction (FPF) of 63 wt.% with low throat deposition (9.0 wt.%) and capsule retention (4.3 wt.%). Computational fluid dynamics analysis showed that at the critical flow rate of 65 l min$^{−1}$, the volume-averaged integral scale strain rate (ISSR) was 5,400 s$^{−1}$, and the average particle impaction velocities were 12.7 and 19.0 m s$^{−1}$ at the inhaler base and grid, respectively. Correlations between the device flow rate and (a) the amount of throat deposition and (b) the capsule emptying times were also developed.The use of CFD has provided further insight into the effect of air flow on the performance of the Aerolizer$^{®}$. The approach of using CFD coupled with powder dispersion is readily applicable to other dry powder inhalers (DPIs) to help better understand their performance optimization.
Starting Page	1445
Ending Page	1453
Page Count	9
File Format	PDF
ISSN	07248741
Journal	Pharmaceutical Research
Volume Number	22
Issue Number	9
e-ISSN	1573904X
Language	English
Publisher	Springer-Verlag
Publisher Date	2005-08-24
Publisher Place	New York
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	CFD, computational fluid dynamics DPI dry powder aerosols inhalation drug delivery Pharmacology/Toxicology Pharmacy Biochemistry Medical Law Biomedical Engineering
Content Type	Text
Resource Type	Article
Subject	Organic Chemistry Pharmacology Molecular Medicine Pharmacology (medical) Biotechnology Pharmaceutical Science

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