NDLI: The Influence of Iontophoresis on Acyclovir Transport and Accumulation in Rabbit Ear Skin

Content Provider	Springer Nature Link
Author	Padula, Cristina Sartori, Francesca Marra, Fabio Santi, Patrizia
Copyright Year	2005
Abstract	The aim of this work was to explore the effect of iontophoresis on acyclovir (ACV) accumulation and permeation. In particular, the objectives were to check the efficacy of the transport mechanisms, electromigration and electroosmosis, on drug accumulation.Permeation experiments were performed in vitro, using rabbit ear skin as barrier, from donor solutions at pH 3.0, 5.8, and 7.4. At the end of the experiments, drug accumulation in epidermis and dermis was measured. Anodal and cathodal iontophoresis were applied at pH 3.0, whereas only anodal iontophoresis was used at pH 5.8 (current densities 0.06–0.50 mA/cm$^{2}$) and 7.4.Cathodal iontophoresis was more efficient than anodal iontophoresis on ACV permeation across the skin at pH 3.0. At pH 5.8, ACV flux and accumulation increased with current density during anodal iontophoresis. At pH 7.4, anodal iontophoresis produced a remarkable increase of flux and a modest increase of accumulation. Overall, anodal flux increased as the pH of the donor solution was increased as a result of the increase of the skin net negative charge.From the results obtained in the present work, it can be concluded that iontophoresis application increases ACV flux and, to a limited extent, accumulation in the skin.
Starting Page	1519
Ending Page	1524
Page Count	6
File Format	PDF
ISSN	07248741
Journal	Pharmaceutical Research
Volume Number	22
Issue Number	9
e-ISSN	1573904X
Language	English
Publisher	Springer-Verlag
Publisher Date	2005-08-24
Publisher Place	New York
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	acetaminophen acyclovir electroosmosis iontophoresis skin transdermal Pharmacology/Toxicology Pharmacy Biochemistry Medical Law Biomedical Engineering
Content Type	Text
Resource Type	Article
Subject	Organic Chemistry Pharmacology Molecular Medicine Pharmacology (medical) Biotechnology Pharmaceutical Science

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in

Transdermal Iontophoretic Delivery of Vapreotide Acetate AcrossPorcine Skin in Vitro

Transdermal Delivery of Heparin Using Pulsed Current Iontophoresis

Transdermal Iontophoresis of Tacrine in Vivo

Drug Reservoir Composition and Transport of Salmon Calcitonin in Transdermal Iontophoresis

Alternating Current (AC) Iontophoretic Transport across Human Epidermal Membrane: Effects of AC Frequency and Amplitude

Effect of Charge and Molecular Weight on Transdermal Peptide Delivery by Iontophoresis

Macromolecules as Novel Transdermal Transport Enhancers for Skin Electroporation

Alteration of Cytokeratin Expression Following Transdermal Lidocaine Hydrochloride Iontophoresis

Transdermal Delivery of Cytochrome C—A 12.4 kDa Protein—Across Intact Skin by Constant–Current Iontophoresis

The Influence of Iontophoresis on Acyclovir Transport and Accumulation in Rabbit Ear Skin

Similar Documents

Transdermal Iontophoretic Delivery of Vapreotide Acetate AcrossPorcine Skin in Vitro

Transdermal Delivery of Heparin Using Pulsed Current Iontophoresis

Transdermal Iontophoresis of Tacrine in Vivo

Drug Reservoir Composition and Transport of Salmon Calcitonin in Transdermal Iontophoresis

Alternating Current (AC) Iontophoretic Transport across Human Epidermal Membrane: Effects of AC Frequency and Amplitude

Effect of Charge and Molecular Weight on Transdermal Peptide Delivery by Iontophoresis

Macromolecules as Novel Transdermal Transport Enhancers for Skin Electroporation

Alteration of Cytokeratin Expression Following Transdermal Lidocaine Hydrochloride Iontophoresis

Transdermal Delivery of Cytochrome C—A 12.4 kDa Protein—Across Intact Skin by Constant–Current Iontophoresis

The Influence of Iontophoresis on Acyclovir Transport and Accumulation in Rabbit Ear Skin