NDLI: Isothermal Crystallization of Imwitor 742 from Supercooled Liquid State

Content Provider	Springer Nature Link
Author	Kawakami, Kohsaku
Copyright Year	2007
Abstract	Crystallization behavior of Imwitor 742 was investigated for use as a liquid-filled capsule carrier.The crystallization behavior of Imwitor 742 was assessed using DSC, X-ray diffraction, and microscopy. The physical stability of Imwitor 742 under refrigerated and ambient conditions was estimated by isothermal crystallization studies using DSC. The effect of hard capsule shells and additives on crystallization kinetics was also examined.When Imwitor 742 was cooled in the DSC measurement, the form α appeared at −20°C. When this form was heated from −40°C, melt-crystallization into the form β + β′ was initiated at −30°C, followed by successive melting. Isothermal crystallization studies at temperatures higher than −14°C yielded the form β + β′. The crystallization behavior was explained in terms of the Avrami model fitting by assuming 2-dimensional crystal growth. Kinetic analysis suggested that the liquid state of Imwitor 742 was maintained for 46 h and 40 months at 5 and 25°C, respectively, although the deviation in induction time was expected to be large at these temperatures. Addition of hard capsule shells promoted the crystallization behavior, while addition of drug or water prolonged the induction time.The supercooled liquid state of Imwitor 742 was quite stable. However, additives to retard crystallization should be used, because the deviation in the induction time was very large. Hard capsule shells enhanced the crystallization of Imwitor 742, possibly by acting as nuclei for crystal growth.
Starting Page	738
Ending Page	747
Page Count	10
File Format	PDF
ISSN	07248741
Journal	Pharmaceutical Research
Volume Number	24
Issue Number	4
e-ISSN	1573904X
Language	English
Publisher	Kluwer Academic Publishers-Plenum Publishers
Publisher Date	2007-02-15
Publisher Place	New York
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	crystallization DSC Imwitor 742 induction time liquid-filled capsules Biomedical Engineering Medical Law Biochemistry Pharmacy Pharmacology/Toxicology
Content Type	Text
Resource Type	Article
Subject	Organic Chemistry Pharmacology Molecular Medicine Pharmacology (medical) Biotechnology Pharmaceutical Science

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